Neo-clerodane diterpenoids from Teucrium kotschyanum

Abstract From the aerial parts of Teucrium kotschyanum three new neo-clerodane diterpenoids have been isolated. Their structures, (12R)-15,16-epoxy-19-nor-10α-neo-cleroda-4,13(16),14-triene-18,6β; 20,12-diolide (12-epiteucvidin), (12R)-15,16-epoxy-19-nor-neo-cleroda-4,13(16),14-triene-18,6β; 20,12-diolide (12-epiteufiin) and (12S,18R)-15,16-epoxy-6β-hydroxy-neo-cleroda-13(16),14-dien-20,12-olide-l8,19-hemiacetal (teukotschyn), have been established by chemical and spectroscopic means. In addition, ursolic acid, the flavones cirsimaritin and cirsiliol, and six previously known neo-clerodane diterpenoids (teucvidin, teuflin, teuscorodin, teucrin H2, teuscorodonin and montanin D) were also fou…