0000000000988063
AUTHOR
Claude Molitor
Mechanochemical Syntheses of N-Containing Heterocycles with TosMIC
A mechanochemical van Leusen pyrrole synthesis with a base leads to 3,4-disubstitued pyrroles in moderate to excellent yields. The developed protocol is compatible with a range of electron-withdrawing groups and can also be applied to the synthesis of oxazoles. Attempts to mechanochemically convert the resulting pyrroles into porphyrins proved to be difficult.
CCDC 2092466: Experimental Crystal Structure Determination
Related Article: Christian Schumacher, Claude Molitor, Sabrina Smid, Khai-Nghi Truong, Kari Rissanen, Carsten Bolm|2021|J.Org.Chem.|86|14213|doi:10.1021/acs.joc.1c01529