0000000000993486
AUTHOR
V Orlando
Comparison among the responses of the greater wax moth, Galleria mellonella and red palm weevil Rhynchophorus ferrugineus to the entomopathogenic nematodes, Steinernema carpocapsae
The entomopathogenic nematode-bacterium complex of Steinernema-Xenorhabdus has high potential as lethal biological control agent against many insect pest species. The Red Palm Weevil (RPW) Rhynchophorus ferrugineus (Coleoptera: Curculionidae) is an important worldwide palm trees pest. This insect is a quarantined pest, accidentally introduced in Sicily in 2005. The pest is killed by Steirnenema carpocapsae, but nematodes are unable to reproduce in the RPW larvae. This research try to understand the reasons of the inability of S. carpocapsae to complete its life cycle in the host comparing what happens in one of the most suitable host, the greater wax moth, Galleria mellonella (Lepidoptera: …
Combining conventional chemotherapy and γδ T cell-based immunotherapy to target cancer-initiating cells.
Colon cancer comprises a small population of cancer initiating stem cells (CIC) that is responsible for tumor maintenance and resistance to anti-cancer therapies, possibly allowing for tumor recapitulation once treatment stops. Combinations of immune-based therapies with chemotherapy and other anti-tumor agents may be of significant clinical benefit in the treatment of colon cancer. However, cellular immune-based therapies have not been experimented yet in the population of colon CICs. Here, we demonstrate that treatment with low concentrations of commonly used chemotherapeutic agents, 5-fluorouracyl and doxorubicin, sensitize colon CICs to Vγ9Vδ2 T cell cytotoxicity. Vγ9Vδ2 T cell cytotoxi…