Association of Oxidative Stress with Aortic Stiffness in Hypertensive Patients with Chronic Kidney Disease

Several studies have consistently demonstrated that arterial stiffness becomes progressively worse as CKD progresses and a negative correlation of oxidative stress with renal function has been described. There is also sound experimental evidence indicating that oxidative stress is involved in atherogenesis. The contribution of oxidative stress to aortic stiffness is less clear. Aim: To analyse the relationship between plasma levels of 8-ISO-prostaglandin F2alpha (8-ISOPGF2alpha), an index of lipid peroxidation, considered a reliable biomarker of oxidative stress, and aortic stiffness in a group of hypertensive patients with chronic kidney disease. Methods: We enrolled 126 hypertensive patie…

EFFETTI DELL'ALLOPURINOLO SUL DECLINO DEL FILTRATO GLOMERULARE IN PAZIENTI IPERTESI CON INSUFFICIENZA RENALE CRONICA

Il ruolo dell’iperuricemia asintomatica quale fattore in grado di favorire in modo indipendente la progressione della malattia renale cronica rimane controverso. Inoltre, gli studi finalizzati a valutare l’influenza della terapia ipouricemizzante sulla evoluzione delle nefropatie croniche sono poco numerosi e hanno dato risultati contrastanti. Scopo del nostro studio osservazionale è stato quello di analizzare retrospettivamente l'effetto del trattamento con allopurinolo, sul declino del filtrato glomerulare, in pazienti ipertesi con insufficienza renale cronica di grado moderato-severo. Sono stati pertanto selezionati 22 pazienti trattati con allopurinolo (A) (100-300 mg/die) che sono stat…

Relationship between aortic stiffness and serum uric acid in essential hypertension

In last years hyperuricemia has been associated with an increased incidence of renal and cardiovascular events in general population, as well as in patients with diabetes and hypertension. However, the role of serum uric acid (SUA) as independent cardiovascular risk factor is still controversial. It is well known that increased aortic stiffness is a powerful independent predictor of cardiovascular events. Little is known about the influence of uric acid on aortic distensibility in subjects with arterial hypertension. The aim of our study was to evaluate the relationships between SUA and aortic stiffness in a group of essential hypertensive patients, attending our Hypertension Centre. We enr…

Relazione tra stiffness aortica ed uricemia nell'ipertensione arteriosa essenziale

RELATIONSHIP BETWEEN OXIDATIVE STRESS AND AORTIC STIFFNESS IN HYPERTENSIVE PATIENTS WITH CHRONIC KIDNEY DISEASE