0000000001004831
AUTHOR
S Drago
An Efficient NURBS Path Generator for a Open Source CNC
In this paper a NURBS path generator (on the plane XY) is proposed to be developed for those CNC machine tools and robot which are Open Source or Opening Architecture. The goal is to use simple and efficient techniques to manufacture geometries which are very complex, whose main feature is the presence of free-form surfaces and contours. To reach this goal, the NURBS path generator has been optimized in order to enable the user to select among three different options to generate the tool path, using a specific parameter. The three options are respectively called “NURBS interpolation with constant increments of u parameter” (NICU), “NURBS interpolation with constant displacement increments b…
Expansion of intestinal CD4+CD25(high) Treg cells in patients with ankylosing spondylitis: a putative role for interleukin-10 in preventing intestinal Th17 response
Objective: subclinical gut inflammation has been demonstrated in ankylosing spondylitis (AS) patients. Aim of this study was to determine the frequency of regulatory CD4+CD25high T cells (Treg), and to evaluate Treg-related cytokines (IL-2, TGF-β, IL-10), and transcription factors (FOXP3 and STAT5) in the ileum of AS patients. Methods: Quantitative gene expression analysis, by rt-PCR, of Treg-related cytokines (IL-2, TGF-β, IL-10) and transcription factor (STAT-5 and FOXP3) was performed on ileal biopsies of 18 AS and 15 active Crohn’s disease (CD) patients, and 15 healthy subjects (HS). Tissue and circulating Treg cells were also analyzed by flow cytometry. Results: A significant up-regula…