0000000001009054

AUTHOR

Katy Gallop

showing 3 related works from this author

NMDA receptor antagonists and pain relief: A meta-analysis of experimental trials

2019

ObjectiveWe conducted a meta-analysis of controlled trials that used experimental models of acute pain and hyperalgesia to examine the analgesic effects of NMDA receptor (NMDAR) antagonists.MethodsSix major databases were systematically searched (to March 2018) for studies using human evoked pain models to compare NMDAR antagonists with no-intervention controls. Pain outcome data were analyzed with random-effects meta-analysis.ResultsSearches identified 70 eligible trials (n = 1,069). Meta-analysis found that low-dose ketamine (<1 mg/kg) produced a decrease in hyperalgesic area (standardized mean difference 0.54, 95% confidence interval [CI] 0.34, 0.74, p < 0.001) and a 1.2-point decr…

pain NMDA ketamine dextromethorphan analgesia review meta-analysisAnalgesicPain reliefDextromethorphanReceptors N-Methyl-D-Aspartate03 medical and health sciences0302 clinical medicine030202 anesthesiologymedicineHumansKetamineAcute painbusiness.industryChronic painModels Theoreticalmedicine.diseaseAcute PainHyperalgesiaAnesthesiaMeta-analysisHyperalgesiaRC0321NMDA receptorKetamineNeurology (clinical)medicine.symptombusinessExcitatory Amino Acid Antagonists030217 neurology & neurosurgerymedicine.drug
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Pain perception in Parkinson's disease: A systematic review and meta-analysis of experimental studies

2017

While hyperalgesia (increased pain sensitivity) has been suggested to contribute to the increased prevalence of clinical pain in Parkinson's disease (PD), experimental research is equivocal and mechanisms are poorly understood. We conducted a meta-analysis of studies comparing PD patients to healthy controls (HCs) in their response to experimental pain stimuli. Articles were acquired through systematic searches of major databases from inception until 10/2016. Twenty-six studies met inclusion criteria, comprising 1292 participants (PD = 739, HCs = 553). Random effects meta-analysis of standardized mean differences (SMD) revealed lower pain threshold (indicating hyperalgesia) in PD patients d…

Agingmedicine.medical_specialtyParkinson's diseaseDopamineAnalgesicDopaminaStimulationDiseaseBiochemistry03 medical and health sciences0302 clinical medicinesystematic reviewDopamineInternal medicineThreshold of painmedicineHumanspain030212 general & internal medicineMolecular Biologybusiness.industryPain PerceptionParkinson DiseaseParkinson’s disease Dopamine Pain Meta-analysis Systematic reviewmedicine.diseasemeta-analysisNeurologyHyperalgesiaMeta-analysisHyperalgesiaPhysical therapyParkinson’s diseaseDoença de Parkinsonmedicine.symptomdopaminebusiness030217 neurology & neurosurgeryBiotechnologymedicine.drug
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Data from: NMDA receptor antagonists and pain relief: a meta-analysis of experimental trials

2019

OBJECTIVES: We conducted a meta-analysis of controlled trials that used experimental models of acute pain and hyperalgesia to examine the analgesic effects of N-methyl-D-aspartate receptor (NMDAR) antagonists. METHODS: Six major databases were systematically searched (to 03/2018) for studies using human evoked pain models to compare NMDAR antagonists with no-intervention controls. Pain outcome data were analyzed with random-effects meta-analysis. RESULTS: Searches identified 70 eligible trials (N=1069). Meta-analysis found that low-dose ketamine (<1 mg/kg) produced a decrease in the size of hyperalgesic area (Standardized Mean Difference=0.54, CI95[0.34, 0.74], p<.001), and a 1.2-poin…

medicine and health caredextromethorphanketamineNMDAMedicineReviewAnalgesiaLife sciences
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