0000000001009074

AUTHOR

Bernadeta Szewczyk

showing 2 related works from this author

Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice

2018

International audience; N-methyl-D-aspartate receptor (NMDAR) modulators induce rapid and sustained antidepressant like-activity in rodents through a molecular mechanism of action that involves the activation of Ca2+ dependent signaling pathways. Moreover, ketamine, a global NMDAR antagonist is a potent, novel, and atypical drug that has been successfully used to treat major depressive disorder (MDD). However, because ketamine evokes unwanted side effects, alternative strategies have been developed for the treatment of depression. The objective of the present study was to determine the antidepressant effects of either a single dose of hyperforin or lanicemine vs. their combined effects in m…

0301 basic medicineSynapsin Iketamine[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/NeurobiologyTRPC 6Pharmacologylcsh:RC321-571TRPC6NMDA - receptor03 medical and health sciencesCellular and Molecular Neurosciencechemistry.chemical_compound0302 clinical medicinemedicinehyperforinlcsh:Neurosciences. Biological psychiatry. NeuropsychiatryMolecular BiologyOriginal ResearchBrain-derived neurotrophic factorChemistrylanicemine[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciencesTail suspension test3. Good healthHyperforin030104 developmental biologyMechanism of actionLaniceminedepressionNMDA receptormedicine.symptom030217 neurology & neurosurgeryNeuroscience
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Antidepressant-like activity of hyperforin and changes in BDNF and zinc levels in mice exposed to chronic unpredictable mild stress.

2019

Abstract Chronic unpredictable mild stress (CUMS) - a rodent model of depression mimics a variety of neurochemical and behavioral alterations similar to those seen in human depression. This study evaluated the antidepressant activity of hyperforin in the CUMS model using fluoxetine (FLX) as a reference drug. The antidepressant-like effects of hyperforin and FLX were evaluated in the tail suspension test (TST), forced swim test (FST), and splash test (SPT). CUMS induced an increase in immobility time in mice (pro-depressive effects) in the FST and TST. CUMS-induced changes were reversed by chronic treatment with hyperforin (2.5 and 5 mg/kg), as well as FLX (10 mg/kg). SPT results revealed a …

Malemedicine.medical_specialtyPhloroglucinolCREBHippocampus03 medical and health sciencesBehavioral Neurosciencechemistry.chemical_compoundMice0302 clinical medicineNeurochemicalInternal medicineFluoxetinemedicineHippocampus (mythology)Animals030304 developmental biology0303 health sciencesFluoxetineDepressive DisorderbiologyDepressionTerpenesBrain-Derived Neurotrophic FactorTail suspension testAntidepressive AgentsFrontal LobeMice Inbred C57BLHyperforinZincEndocrinologychemistrybiology.proteinAntidepressant030217 neurology & neurosurgeryStress Psychologicalmedicine.drugBehavioural despair testBehavioural brain research
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