0000000001012743

AUTHOR

Elisabeth Altmaier

showing 2 related works from this author

Meta-analysis of exome array data identifies six novel genetic loci for lung function

2018

Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and three lung function measures: forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and the ratio of FEV1 to FVC (FEV1/FVC). These analyses by the SpiroMeta and CHARGE consortia included 60,749 individuals of European ancestry from 23 studies, and 7,721 individuals of African Ancestry from 5 studies in the discovery stage, with follow-up in up to 111,556 independent individuals. Results: We identified significant (P<2·8x10-7) associatio…

0301 basic medicineNonsynonymous substitutionVital capacityMedicine (miscellaneous)Genome-wide association studySingle-nucleotide polymorphismBiologyGenomeGeneral Biochemistry Genetics and Molecular Biologyhengityselimet03 medical and health sciencesFEV1/FVC ratio0302 clinical medicineMedicine and Health SciencesmedicineCOPDGWASkeuhkotExome030304 developmental biologyGenetics0303 health sciencesCOPDexome arrayta1184Lung function respiratory exome array GWAS COPDBiology and Life Sciencesta3141lung functionArticlesGenomicsta3121respiratory systemrespiratorymedicine.diseaserespiratory tract diseases030104 developmental biology030220 oncology & carcinogenesisExpression quantitative trait lociResearch Article
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Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study.

2008

Exposure to nicotine during smoking causes a multitude of metabolic changes that are poorly understood. We quantified and analyzed 198 metabolites in 283 serum samples from the human cohort KORA (Cooperative Health Research in the Region of Augsburg). Multivariate analysis of metabolic profiles revealed that the group of smokers could be clearly differentiated from the groups of former smokers and non-smokers. Moreover, 23 lipid metabolites were identified as nicotine-dependent biomarkers. The levels of these biomarkers are all up-regulated in smokers compared to those in former and non-smokers, except for three acyl-alkyl-phosphatidylcholines (e.g. plasmalogens). Consistently significant r…

Nicotinemedicine.medical_specialtyPublic Health and Epidemiology/Environmental HealthMetabolitelcsh:MedicineBiologyPharmacologyCohort StudiesNicotinechemistry.chemical_compoundInternal medicineDiabetes and Endocrinology/EndocrinologyGene expressionmedicineMetabolomeCluster AnalysisHumansAlkylglycerone-phosphate synthaselcsh:Sciencechemistry.chemical_classificationAlkyl and Aryl TransferasesMultidisciplinarySmokinglcsh:RLipid metabolismPublic Health and Epidemiology/Global HealthChemical Biology/Small Molecule ChemistryEnzymeEndocrinologychemistryBiochemistry/Small Molecule ChemistryGlycerophospholipidMetabolomePhosphatidylcholineslcsh:Qbiology.geneMental Health/Personality DisordersBiomarkersResearch Articlemedicine.drugPLoS ONE
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