0000000001017588

AUTHOR

Cheryl Lassen

showing 4 related works from this author

Blinded 12-week comparison of once-daily indacaterol and tiotropium in COPD.

2011

Two, once daily (q.d.) inhaled bronchodilators are available for the treatment of chronic obstructive pulmonary disease (COPD): the β(2)-agonist indacaterol and the anticholinergic tiotropium. This blinded study compared the efficacy of these two agents and assessed their safety and tolerability. Patients with moderate-to-severe COPD were randomised to treatment with indacaterol 150 μg q.d. (n=797) or tiotropium 18 μg q.d. (n=801) for 12 weeks. After 12 weeks, the two treatments had similar overall effects on "trough" (24 h post-dose) forced expiratory volume in 1 s. Indacaterol-treated patients had greater improvements in transition dyspnoea index (TDI) total score (least squares means 2.0…

Pulmonary and Respiratory MedicineSpirometryMalemedicine.drug_classScopolamine DerivativesQuinolonesSeverity of Illness IndexCholinergic AntagonistsDrug Administration ScheduleMedical Recordslaw.inventionPulmonary Disease Chronic ObstructiveRandomized controlled trialDouble-Blind MethodlawAdrenergic beta-2 Receptor AntagonistsForced Expiratory VolumemedicineAnticholinergicHumansTiotropium BromideAdverse effectAgedCOPDmedicine.diagnostic_testbusiness.industryTiotropium bromideMiddle Agedmedicine.diseaserespiratory tract diseasesBronchodilator AgentsTreatment OutcomeTolerabilitySpirometryAnesthesiaIndansIndacaterolFemalebusinessmedicine.drugThe European respiratory journal
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ONCE-DAILY INDACATEROL PROVIDES SUPERIOR BRONCHODILATION, HEALTH STATUS AND CLINICAL OUTCOMES COMPARED WITH SALMETEROL IN PATIENTS WITH CHRONIC OBSTR…

2009

Pulmonary and Respiratory MedicineCOPDmedicine.medical_specialtybusiness.industryTreatment outcomePlacebo-controlled studyCritical Care and Intensive Care Medicinemedicine.diseaseInternal medicineBronchodilationmedicineIndacaterolIn patientSalmeterolOnce dailyCardiology and Cardiovascular Medicinebusinessmedicine.drugChest
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Indacaterol Provides Effective Bronchodilation In Patients With Chronic Obstructive Pulmonary Disease Irrespective Of Patient Age (<65 Or e65 Year…

2010

medicine.medical_specialtyPatient agebusiness.industryInternal medicineBronchodilationmedicineCardiologyIndacaterolPulmonary diseaseIn patientbusinessmedicine.drugC41. EMERGING PHARMACOLOGY FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE: MECHANISMS AND OUTCOMES
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Indacaterol once-daily provides superior efficacy to salmeterol twice-daily in COPD: A 12-week study

2011

SummaryBackgroundIndacaterol is a novel, inhaled once-daily ultra-long-acting β2-agonist for the treatment of COPD.MethodsThis 12-week randomised, parallel-group study compared the efficacy of indacaterol 150 μg once-daily to salmeterol 50 μg twice-daily in patients with moderate-to-severe COPD. Assessments included FEV1 standardised area under curve (AUC) from 5 min to 11 h 45 min at Week 12 (primary endpoint), 24-h trough FEV1 (mean of 23 h 10 min and 23 h 45 min post-dose) at Week 12 (key secondary endpoint), FEV1 and FVC measured over 24-h, transition dyspnoea index (TDI) and rescue medication use.ResultsOf 1123 patients randomised 92.1% completed. Mean ± SD age was 62.8 ± 8.78 years, p…

MalePulmonary and Respiratory Medicinemedicine.drug_classbeta2-agonistQuinolonesDrug Administration Schedulelaw.inventionFEV1/FVC ratioPulmonary Disease Chronic ObstructiveRandomized controlled trialDouble-Blind MethodlawBronchodilatorForced Expiratory VolumeClinical endpointmedicineCOPDHumansAlbuterolSalmeterolSalmeterol XinafoateIndacaterolCOPDDose-Response Relationship Drugbusiness.industryrespiratory systemMiddle Agedmedicine.diseaserespiratory tract diseasesBronchodilator AgentsRespiratory Function TestsTreatment OutcomeAnesthesiaIndansIndacaterolFemaleSalmeterolOnce dailybusinessBronchodilatormedicine.drugRespiratory Medicine
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