0000000001017702

AUTHOR

Irene Miccichè

showing 2 related works from this author

Acetaldehyde as the first hit of addictive behaviour

2016

Unhealthy alcohol use is common in the Western society, which puts risk of health consequences, causing multiple behavioural injuries. Increasing evidence focuses on acetaldehyde, the first metabolite of ethanol, as the mediator of the several behavioural actions of alcohol, including its rewarding and motivational effects. In particular, acetaldehyde induces dopamine release in the nucleus accumbens modulating primary alcohol rewarding effect, drug seeking, and relapse behaviour. Recent behavioural studies point at acetaldehyde as a drug of abuse since its oral self-administration is induced and maintained in an operant/conflict paradigm. These findings provide further evidence on the role…

0301 basic medicinemedicine.medical_specialtyAddictive behaviourmedia_common.quotation_subjectAlcohol abuseAlcoholAcetaldehydePlant SciencePharmacologyNucleus accumbensGeneral Biochemistry Genetics and Molecular BiologyEthanol-related effect03 medical and health scienceschemistry.chemical_compound0302 clinical medicineMediatorDopamineEthanol-related effectsAcetaldehyde; Addictive behaviour; Ethanol-related effects; Biochemistry Genetics and Molecular Biology (all); Plant Science; Biochemistry (medical)medicinePsychiatrylcsh:QH301-705.5media_commonBiochemistry Genetics and Molecular Biology (all)EthanolAddictionBiochemistry (medical)Acetaldehydemedicine.disease030104 developmental biologylcsh:Biology (General)chemistryPsychology030217 neurology & neurosurgerymedicine.drugJournal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale
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The Use of Intravenous Fosfomycin in Clinical Practice: A 5-Year Retrospective Study in a Tertiary Hospital in Italy

2023

Fosfomycin in intravenous (IV) formulation has re-emerged as a valuable tool in the treatment of multi-drug resistant (MDR) and extensively drug-resistant (XDR) infections because of its broad spectrum of antibacterial action and pharmacokinetic characteristics. This retrospective study aimed to evaluate how fosfomycin was used in patients admitted to the Polyclinic of Palermo between January 2017 and July 2022. Clinical indications, therapeutic associations, clinical outcomes, and any side effects were analyzed. Intravenous fosfomycin was used in 343 patients, 63% male, with a mean age of 68 years (range 15–95). Urinary tract infections (UTIs) and hospital-acquired pneumonia (HAP) were the…

Microbiology (medical)Infectious Diseasesretrospective study.fosfomycin; antimicrobials; gram-negative; retrospective studyantimicrobialPharmacology (medical)General Pharmacology Toxicology and PharmaceuticsfosfomycinBiochemistryMicrobiologygram-negativeAntibiotics; Volume 12; Issue 6; Pages: 971
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