0000000001019433

AUTHOR

Nuno Fachada

0000-0002-8487-5837

showing 2 related works from this author

TopoCell – An image analysis tool to study intracellular topography

2012

Computer sciencebusiness.industryGeneticsComputer visionArtificial intelligencebusinessMolecular BiologyBiochemistryIntracellularBiotechnologyImage (mathematics)The FASEB Journal
researchProduct

Enlarged PLIN5-uncoated lipid droplets in inner regions of skeletal muscle type II fibers associate with type 2 diabetes

2022

Skeletal muscle physiology remains of paramount importance in understanding insulin resistance. Due to its high lipid turnover rates, regulation of intramyocellular lipid droplets (LDs) is a key factor. Perilipin 5 (PLIN5) is one of the most critical agents in such regulation, being often referred as a protector against lipotoxicity and consequent skeletal muscle insulin resistance. We examined area fraction, size, subcellular localization and PLIN5 association of LDs in two fiber types of type 2 diabetic (T2D), obese (OB) and healthy (HC) individuals by means of fluorescence microscopy and image analysis. We found that T2D type II fibers have a significant sub-population of large and inter…

Histologylipid dropletsMuscle Fibers SkeletalSkeletal musclelihaksetlipiditPerilipin-5Type II diabetesSDG 3 - Good Health and Well-beinginsulin resistanceHumansskeletal muscleMuscle SkeletalInsulin resistanceCell BiologyGeneral MedicineLipid MetabolismLipid dropletsinsuliiniresistenssifiber typePLIN5Diabetes Mellitus Type 2/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingproteiinitFiber typeaikuistyypin diabetes
researchProduct