0000000001024775
AUTHOR
S Colafrancesco
ESTREMO/WFXRT: Extreme phySics in the TRansient and Evolving COsmos
We present a mission designed to address two main themes of the ESA Cosmic Vision Programme: the Evolution of the Universe and its Violent phenomena. ESTREMO/WFXRT is based on innovative instrumental and observational approaches, out of the mainstream of observatories of progressively increasing area, i.e.: Observing with fast reaction transient sources, like GRB, at their brightest levels, thus allowing high resolution spectroscopy. Observing and surveying through a X-ray telescope with a wide field of view and with high sensitivity extended sources, like cluster and Warm Hot Intragalactic Medium (WHIM). ESTREMO/WFXRT will rely on two cosmological probes: GRB and large scale X-ray structur…
Safety profile of the interleukin-1 inhibitors anakinra and canakinumab in real life clinical practice: a nationwide multicenter retrospective observational study
A few studies have reported the safety profile of interleukin (IL)-1 blockers from real life. The aim of this study is to describe anakinra (ANA) and canakinumab (CAN) safety profile in children and adults, based on data from a real-life setting. Demographic, clinical, and therapeutic data from patients treated with ANA and CAN were retrospectively collected and analyzed. Four hundred and seventy five patients were enrolled; ANA and CAN were prescribed in 421 and 105 treatment courses, respectively. During a mean follow-up of 24.39 ± 27.04 months, 89 adverse events (AE) were recorded; 13 (14.61%) were classified as serious AE (sAE). The overall estimated rate of AE and sAE was 8.4 per 100 p…