0000000001030012

AUTHOR

Lutz Birnbaumer

showing 2 related works from this author

Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis

2017

Fil: Chrétien, Chloé. University of Bourgogne Franche-Comté. Institut National de la Recherche Agronomique. Centre des Sciences du Goût et de l’Alimentation; France Fil: Fenech, Claire. University of Bourgogne Franche-Comté. Institut National de la Recherche Agronomique. Centre des Sciences du Goût et de l’Alimentation; France Fil: Liénard, Fabienne. University of Bourgogne Franche-Comté. Institut National de la Recherche Agronomique. Centre des Sciences du Goût et de l’Alimentation; France Fil: Grall, Sylvie. University of Bourgogne Franche-Comté. Institut National de la Recherche Agronomique. Centre des Sciences du Goût et de l’Alimentation; France Fil: Chevalier, Charlène. University of …

Male0301 basic medicine[ SDV.AEN ] Life Sciences [q-bio]/Food and NutritionEndocrinology Diabetes and Metabolismmedicine.medical_treatmentsourisTRPC3proopiomelanocortin neuronsEnergy homeostasisRats Sprague-DawleyEatingMiceTransient receptor potential channelneuropeptide-yTRPC3synaptic-transmissionneuroneInsulin SecretionHomeostasisInsulinarcuate nucleusNeurons2. Zero hungerneuropeptide ydiabetesion channelsnoyau arquémuscle squelettiqueFastingfood-intakeprise alimentaire16. Peace & justiceNeuropeptide Y receptorcation channelsproopiomelanocortine3. Good healthMedicina BásicaAlimentation et NutritionEndocrinologie et métabolismemedicine.medical_specialtyCIENCIAS MÉDICAS Y DE LA SALUDBlotting Westernarcuate nucleus;food-intake;synaptic-transmission;endothelial-cell;skeletal-muscle;cation channel;neuropeptide-y;ion channel;mouse;proopiomelanocortin neuronHypothalamusInmunologíaMédecine humaine et pathologieBiologyNeurotransmissionReal-Time Polymerase Chain ReactionHOMEOSTASIS ENERGETICA03 medical and health sciencesCalcium imagingInternal medicineInternal MedicinemedicineFood and NutritionAnimalsskeletal-musclecanal ioniquemouseTRPC Cation ChannelsEndocrinology and metabolismInsulinBody Weighttransmission synaptiqueGlucose Tolerance TestRatsMice Inbred C57BLGlucose030104 developmental biologyEndocrinologyendothelial-cellsGLUCOSA HIPOTALAMICAHypothalamic glucose sensingAnorecticHuman health and pathologyCANALES IONICOSEnergy Metabolismcellule endotheliale[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
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Implication of TRPC3 channel in gustatory perception of dietary lipids

2020

Aim The pathogenesis of obesity has been associated with high intake of dietary fat, and some recent studies have explored the cellular mechanisms of oro-sensory detection of dietary fatty acids. We further assessed the role of transient receptor potential canonical (TRPC) channels in oro-sensory perception of dietary lipids. Methods We determined by RT-qPCR and western blotting the expression of TRPC3/6/7 channels in mouse fungiform taste bud cells (mTBC). Immunocytochemistry was used to explore whether TRPC3 channels were co-expressed with fatty acid receptors. We employed wild-type (WT) mTBC, and those transfected with small interfering RNAs (siRNAs) against TRPC3 or STIM1. Ca2+ signalli…

0301 basic medicinemedicine.medical_specialtyTastePhysiologyCD36030204 cardiovascular system & hematologyTRPC6Food PreferencesMice03 medical and health sciencesTransient receptor potential channel0302 clinical medicineTRPC3Internal medicineTaste budmedicineAnimalsTRPCTRPC Cation Channelschemistry.chemical_classificationbiologyChemistryTaste PerceptionFatty acidDietary FatsLipids030104 developmental biologyEndocrinologymedicine.anatomical_structurebiology.proteinActa Physiologica
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