Type-II Transmembrane Prolyl Dipeptidases and Matrix Metalloproteinases in Membrane Vesicles of Active Endothelial Cells

2006

Endothelia cells in sparse culture are migratory and increase the production of gelatinases of serine- and metallo-classes in membrane vesicles. Collectively, proteases associated with membrane vesicles degrade extracellular matrix components including type-I and type-IV collagens, laminin and fibronectin. Inhibitor studies suggest the existence of small gelatinases that were derived from these serine- and metallo-proteases. Thus, further studies are warranted to demonstrate the cooperative action of metallo- and serine proteases on cell surfaces and in extracellular vesicles during endothelial cell migration in 3D collagenous matrices, and potential proteolytic activation mechanism for the…

Clustering of type-II transmembrane serine proteases (TTSPs) and matrix metalloproteases (MMPs) in the cell surface and shed membrane vesicles of act…

2005

CLUSTERING OF TYPE-II TRANSMEMBRANE SERINE PROTEASES (TTSPS) AND MATRIX METALLOPROTEINASES (MMPS) IN THE CELL SURFACE AND SHED MEMBRANE VESICLES OF A…

2006

Proteolytic enzymes in membrane domains of endothelial cells cultured in type-1 collagen 3D gels

2005

Proteolytic enzymes clustered in specialized plasma membrane domains generate permissive substrates for endothelial cell migration

2007

Proteolytic enzymes in membrane domains of endothelial cells cultured in type-I collagen 3D gels

2005

Espressione ed associazione di enzimi proteolitici durante la transizione epitelio/mesenchima in cellule endoteliali.

2006

Clustering and Proteolytic enzymes complexes formation in specialized plasma membra domains of endothelial cells. Role in angiogenesis.

2007

Clustering of type-II transmembrane serine proteases (TTSPs) and matrix metalloproteinases (MMPs) in the cell surface and shed membrane vesicles of a…

2005

CLUSTERING OF PROTEOLYTIC ENZYMES ON SPECIALIZED PLASMA MEMBRANE DOMAINS OF ENDOTHELIAL CELLS. ROLE IN ANGIOGENESIS

2004