0000000001033582
AUTHOR
M Gargiulo
Antiretroviral genotypic resistance in plasma RNA and whole blood DNA in HIV-1 infected patients failing HAART
The extent to which HIV-1 proviral DNA mutations cause clinically relevant antiretroviral resistance is still controversial. Paired plasma HIV-1 RNA and whole blood DNA were compared in patients failing HAART to investigate if the additional knowledge of archived mutations could improve the selection of potentially active drugs. Seventy-three HIV-1-infected patients with first/second HAART failure were studied before starting a new regimen based on RNA genotyping. Follow-up data after a 12-week therapy were available. DNA genotyping was retrospectively performed on stored whole blood samples and mutational profiles were compared to those from RNA. The mean number of IAS pol mutations was si…
HIGH VISCERAL ADIPOSITY INDEX (VAI) SCORE BEFORE AND AFTER TREATMENT IN YOUNGH HIV-POSITIVE PATIENTS
The new therapies in HIV-positive patients are extremely effective in terms of immunological response. In western countries the mortality rate was reduced by 100% from 1984 to the current 8.8%. HIV people are now patients with a chronic disease characterized by also metabolic disorders. Long term virus alterations and treatment sideeffects induced lipid disorders, in particular hypercholesterolemia and hypertriglyceridemia. To assess cardiovascular risk (CVR) in HIV patients. From April 2012 to January 2013 we evaluated 20 HIV-positive naive patients, no HBV-HCV coinfected (19 males, age range 21-42 years, mean 31.8 + 4.8, BMI 23.5 + 3.8). Before and after inhibitor proteases (IP) treatment…