0000000001034399

AUTHOR

Ursula Kühs

showing 1 related works from this author

Expression patterns and prognostic role of transketolase-like 1 in muscle-invasive bladder cancer

2015

PURPOSE: The pentose phosphate pathway (PPP) has been shown to play an important role in the metabolism of cancer cells. The transketolase-like 1 gene (TKTL1) encodes an enzyme representing an essential component of this pathway. Its expression has been demonstrated to correlate with stage and outcome in various tumors. The aim of the present study was to assess expression patterns and the prognostic role of TKTL1 in muscle-invasive bladder cancer (MIBC). PATIENTS AND METHODS: The expression of TKTL1 was assessed in a tissue microarray consisting of histopathologically benign and malign tissue of 112 patients who underwent radical cystectomy due to MIBC. Cytoplasmatic and nuclear expression…

AdultMalemedicine.medical_specialtyGlycolysiUrologymedicine.medical_treatmentBiopsyDiabetePentose phosphateSettore MED/24 - UrologiaCystectomyInternal medicineBiopsymedicineHumansNeoplasm InvasivenessUrotheliumLymph nodeAgedRetrospective StudiesAged 80 and overBladder cancerTissue microarraymedicine.diagnostic_testbusiness.industryBladder cancerTransketolase-like 1DNA NeoplasmBiomarkerMiddle Agedmedicine.diseaseImmunohistochemistryGene Expression Regulation Neoplasticmedicine.anatomical_structureEndocrinologyUrinary Bladder NeoplasmsTissue Array AnalysisCancer cellCancer researchImmunohistochemistryFemaleTransketolaseUrotheliumbusinessFollow-Up Studies
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