0000000001039778
AUTHOR
Ana Gil-brusola
Towards next-generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomics.
5 páginas, 2 figuras. AVAILABILITY AND IMPLEMENTATION: The database of non-tuberculous mycobacteria assemblies can be accessed at: 10.5281/zenodo.3374377. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online: http://dx.doi.org/10.1093/bioinformatics/btz729
Towards next generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomics
AbstractTuberculosis remains one of the main causes of death worldwide. The long and cumbersome process of culturingMycobacterium tuberculosiscomplex (MTBC) bacteria has encouraged the development of specific molecular tools for detecting the pathogen. Most of these tools aim to become novel tuberculosis diagnostics, and big efforts and resources are invested in their development, looking for the endorsement of the main public health agencies. Surprisingly, no study had been conducted where the vast amount of genomic data available is used to identify the best MTBC diagnostic markers. In this work, we use large-scale comparative genomics to provide a catalog of 30 characterized loci that ar…
Caracterización epidemiológica, clínica, microbiológica y genómica de Mycobacterium tuberculosis en el Departamento de Salud La Fe de Valencia
Tesis doctoral, 152 págs