0000000001043994

AUTHOR

Edita Gasiuniene

showing 2 related works from this author

Evaluation of proteasomal gene polymorphisms in Lithuanian patients with asthma.

2014

To investigate polymorphisms of proteasomal genes PSMA6 (rs1048990 and rs2277460), PSMC6 (rs2295826 and rs2295827) and PSMA3 (rs2348071) in Lithuanian patients with asthma.One-hundred forty-six asthma patients and 150 control subjects were studied. DNA was extracted from peripheral blood samples. Five single nucleotide polymorphisms (SNP's) of the three proteasomal genes were analyzed using allele-specific amplification or the cleaved amplified polymorphic sequence method.While certain alleles and genotypes of PSMA6 rs2277460 and rs1048990 and PSMA3 rs2348071 SNP's occurred more frequently in asthma patients than in controls, no statistically significant differences in alleles or genotypes …

Pulmonary and Respiratory MedicineAdultMaleProteasome Endopeptidase ComplexGenotypePSMA6Single-nucleotide polymorphismPolymorphism Single NucleotidePSMC6Sex FactorsGenotypeCleaved amplified polymorphic sequencemedicineImmunology and AllergySNPHumansGenetic Predisposition to DiseaseAlleleAllelesAsthmabusiness.industryLithuaniaMiddle Agedmedicine.diseaseAsthmaRespiratory Function TestsPediatrics Perinatology and Child HealthImmunologyFemalebusinessThe Journal of asthma : official journal of the Association for the Care of Asthma
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The Burden of Allergic Asthma in Children: A Landscape Comparison Based on Data from Lithuanian, Latvian, and Taiwanese Populations

2012

Asthma is one of the most common chronic respiratory diseases with an increasing prevalence and financial burden worldwide. This disease affects individuals in all countries and all ethnic groups; however, prevalence rates of asthma have been reported to vary significantly between different regions. To understand the origin of asthma and to manage it effectively, it is necessary to analyze the genetic and environmental factors that cause these geographic differences. Therefore, we aimed to review published data from the investigations of asthma patients in Eastern Europe, represented by Latvia and Lithuania, and of patients from Eastern Asia represented by Taiwan. We hope that some of the c…

MalePediatricsmedicine.medical_specialtyAdolescentprevalenceTaiwanEthnic groupPrevalenceDiseaseSeverity of Illness Indexdisease burdenCost of Illnesschildhood asthmaEnvironmental healthmedicineHumansEast AsiaPediatrics Perinatology and Child HealthChildDisease burdenAsthmabusiness.industrylcsh:RJ1-570Latvianlcsh:PediatricsLithuaniaLithuanianmedicine.diseaseLatviaAsthmalanguage.human_languageTreatment OutcomeChild PreschoolChronic DiseasePediatrics Perinatology and Child HealthlanguageFemalebusinessPediatrics & Neonatology
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