0000000001051131
AUTHOR
G. Neri
Geophysical investigations along the Tyrrhenian shore of Calabria
The Tyrrhenian Sea is a widely investigated basin developed in the Mediterranean area within the frame of Europe- Africa convergence and Ionian plate subduction process (Faccenna et al., 2014; Orecchio et al., 2014 and references therein). Since the Late Miocene, extension within the Tyrrhenian Sea was associated with coeval shortening in the Apennines-Maghrebide orogen and progressive southeastward rollback of the Ionian subducting plate. In this framework both extension and widespread volcanism well represented by the Vavilov and Marsili basins and the Aeolian volcanic arc, are typical features of the Tyrrhenian Sea region. Several authors (De Ritis et al., 2010; Loreto et al., 2015 and r…
Treatment of central and sensorineural tinnitus with orally administered Melatonin and Sulodexide: personal experience from a randomized controlled study.
Since very little is understood about the exact aetiology of tinnitus, this has made treatment of the condition difficult. Even though approximately 10-15% of the general population suffer from tinnitus, only 2% consider it serious enough to warrant any treatment. The main problem arising from tinnitus is the disturbance it causes not only in day to day life but also in sleep, leading to fatigue and general discomfort. The present study focused on the effect of Melatonin in conjunction with Sulodexide as a treatment method for tinnitus. Overall, 102 patients suffering from tinnitus were evaluated in a prospective randomised controlled study conducted in a tertiary care ENT department. After…
GERMLINE PROKINETICIN RECEPTOR 2 (PROKR2) VARIANTS ASSOCIATED WITH CENTRAL HYPOGONADISM CAUSE DIFFERENTAL MODULATION OF DISTINCT INTRACELLULAR PATHWAYS.
INTRODUCTION: Defects of prokineticin pathway affect the neuroendocrine control of reproduction, but their role in the pathogenesis of central hypogonadism remains undefined, and the functional impact of the missense PROKR2 variants has been incompletely characterized. MATERIAL AND METHODS: In a series of 246 idiopathic central hypogonadism patients, we found three novel (p.V158I, p.V334M, and p.N15TfsX30) and six already known (p.L173R, p.T260M, p.R268C, p.V274D, p.V331M, and p.H20MfsX23) germline variants in the PROKR2 gene. We evaluated the effects of seven missense alterations on two different prokineticin receptor 2 (PROKR2)-dependent pathways: inositol phosphate-Ca(2+) (Gq coupling) a…