0000000001051550

AUTHOR

M. Di Foggia

showing 1 related works from this author

Chemical and physical characterization of thermal aggregation of model proteins modulated by zinc(II) and copper(II) ions

2016

BACKGROUND: Metal ions are implicated in protein aggregation processes of several neurodegenerative pathologies, where the protein deposition occurs, and in the biotechnology field like the food technology where many processes in food manufacturing are based on thermal treatments. OBJECTIVE: The influence of Cu2+ or Zn2+ ions on the thermal aggregation process of Bovine beta-lactoglobulin (BLG) and Bovine Serum Albumin (BSA), two protein models, was studied with the aim of delineating the role of these ions in the protein aggregation kinetics and to clarify the related molecular mechanisms. METHODS: The protein structure changes were monitored by Raman spectroscopy, whereas the aggregate gr…

inorganic chemicals0301 basic medicineMetal ions in aqueous solutionKineticsInorganic chemistryBeta-lactoglobulinchemistry.chemical_elementZincProtein aggregation010402 general chemistry01 natural sciencesBovine Serum Albumin (BSA)Beta-lactoglobulin bovine serum albumin (BSA) copper and zinc ionsRaman spectroscopy dynamic light scatteringMetal03 medical and health sciencesProtein structureDynamic light scatteringcopper and zinc ionRadiology Nuclear Medicine and imagingcopper and zinc ionsBovine serum albuminBeta-lactoglobulin; Bovine Serum Albumin (BSA); copper and zinc ions; Raman spectroscopy; dynamic light scatteringbiologydigestive oral and skin physiologydynamic light scattering0104 chemical sciences030104 developmental biologychemistryvisual_artRaman spectroscopyBiophysicsbiology.proteinvisual_art.visual_art_medium
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