0000000001052575

AUTHOR

A Cusimano

showing 5 related works from this author

Gene expression profiling of human liver cancer cells following celecoxib tretment

2010

Celecoxibglobal gene expression analysisHCCCOX-2microarray
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Altered gene expression profiles in liver cancer cells upon sorafenib treatment

2010

global gene expression analysisSorafenibHCCmicroarray
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Antitumor activity of the novel small molecule Akt inhibitor SC66 in hepatocellular carcinoma cells.

2013

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide characterized by poor and often limited or no response to current drug therapies. The PI3K/Akt/mTOR pathway is a key regulator of cell proliferation and survival. Alterations in this pathway have been reported in many types of human cancer, including HCC. It has become evident that Akt inhibitors have great potential in cancer treatment. SC66 is a new allosteric Akt inhibitor that facilitates ubiquitination of Akt, favoring its degradation via the proteasome, thus inhibiting Akt signaling. In the present study, we investigated the anticancer activity of SC66 in HCC cell lines (HepG2, Huh7, Hep3B, PLC/PRF/5 and HA22T/VG…

Settore MED/12 - GastroenterologiaSettore BIO/14 - FarmacologiaHepatocellular carcinoma Akt SC66 Inhibitor
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Contagious agalactiae: a preliminary study on its impact on milk production of Sicilian sheep

2014

Mycoplasma agalactiaeSettore AGR/19 - Zootecnica Specialemilk losses
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Un'analisi controfattuale degli incentivi agli investimenti infrastrutturali per lo sviluppo locale: il caso dei PIT

2016

Incentivi Infrastrutture Sviluppo Locale Progetti Integrati Analisi ControfattualeSettore SECS-P/02 Politica Economica
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