Author: Judit Jiménez Sainz

0000000001052787

AUTHOR

Judit Jiménez Sainz

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PINK1: a critical protein kinase in the molecular mechanisms involved in Cancer and Parkinson's disease

2012

El cáncer y la enfermedad de Parkinson (PD) son dos enfermedades en las que el mecanismo pato- fisiológico final no está completamente definido. Datos epidemiológicos indican que los pacientes con PD poseen bajo riesgo de cáncer, con la excepción de melanoma maligno y cánceres de piel, tiroides y mama, lo que sugiere una conexión funcional entre PD y cáncer. Apoyando esta conexión, la desregulación de la homeostasis mitocondrial es una característica importante en la patogénesis de ambas enfermedades. Recientemente, varios genes asociados a PD, tales como Parkin, LRRK2, DJ-1, y PINK1, han sido propuestos como moduladores de procesos cancerígenos. Mutaciones en el gen de PINK1 están asociada…

:CIENCIAS DE LA VIDA::Bioquímica [UNESCO]UNESCO::CIENCIAS DE LA VIDA::Biología molecularPINK1proliferationUNESCO::CIENCIAS DE LA VIDA::Bioquímicainvasion:CIENCIAS DE LA VIDA::Biología molecular [UNESCO]mitochondriacell deathmitophagySer/Thr kinaseparkinson's diseaseoxidative stresscancercell cyclemitochondrial homeostasis

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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LSLife Sciences
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