0000000001054196
AUTHOR
Sergio Migliore
showing 3 related works from this author
Additional file 2: of Two novel amino acid substitutions in highly conserved regions of prion protein (PrP) and a high frequency of a scrapie protect…
2019
Table of the genotypes combinations of Prion protein gene in native Ethiopian goats.. (PDF 423 kb)
Two novel amino acid substitutions in highly conserved regions of prion protein (PrP) and a high frequency of a scrapie protective variant in native …
2019
Background Polymorphisms of the prion protein gene may influence scrapie susceptibility in small ruminants through modified protein conformation. At least 47 amino acid substitutions and 19 silent polymorphisms have been described in goat PRNP reported from several countries. The objective of this study was to investigate PRNP polymorphisms of native Ethiopian goat breeds and compare the results with other goat breeds. Results The analysis of the prion protein gene PRNP in 229 goats belonging to three of the main Ethiopian native goat breeds showed a remarkably high frequency (> 34.6%) of p.(Asn146Ser) in these breeds, a variant involved in scrapie resistance in Cyprus. In addition, two nov…
Additional file 1: of Two novel amino acid substitutions in highly conserved regions of prion protein (PrP) and a high frequency of a scrapie protect…
2019
Prion protein gene polymorphism in native Ethiopian goats. Excel file that include all information related to each single goat in the three Ethiopian regions. For each goat, information regarding sex, age in months and the related prion polymorphisms are reported. (XLS 60 kb)