0000000001055308

AUTHOR

Neurath M F

showing 2 related works from this author

Regulation of Protein-DNA Interactions at the Interferon-gamma Gene Promoter by Corticosteroids

1998

CD4-Positive T-LymphocytesTranscription GeneticRecombinant Fusion ProteinsProtein dnaBiologyLymphocyte ActivationTransfectionDexamethasoneGeneral Biochemistry Genetics and Molecular BiologyInterferon-gammaHistory and Philosophy of ScienceAdrenal Cortex HormonesAntigens CDGenes ReportermedicineHumansInterferon gammaInterleukin 29Promoter Regions GeneticCells CulturedGeneral NeurosciencePromoterTATA BoxMolecular biologyTranscription Factor AP-1Cancer researchLeukocyte Common AntigensTetradecanoylphorbol Acetatemedicine.drugAnnals of the New York Academy of Sciences
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Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo.

2004

Background: Interleukin 18 (IL-18) is a cytokine with pleiotropic activity that augments T helper 1 responses and cytotoxic activity of natural killer cells. Methods: To assess the function of IL-18 in vivo, we generated IL-18 transgenic (IL-18 Tg) mice under the control of a CD2 promoter/enhancer construct. Results: Macroscopically, IL-18 Tg mice showed reduced relative liver weight compared with wild-type littermates. TUNEL assays demonstrated increased hepatocyte apoptosis, and primary hepatocytes isolated from IL-18 Tg mice exhibited an increased spontaneous apoptosis rate. Furthermore, cross linking of Fas increased significantly the apoptosis rate in hepatocytes isolated from wild- ty…

Genetically modified mousemedicine.medical_specialtyTransgeneT-LymphocytesApoptosisMice TransgenicMice SCIDBiologyTransfectionTranslocation GeneticInterferon-gammaMiceIn vivoInternal medicinemedicineCytotoxic T cellAnimalsfas ReceptorL-SelectinCells CulturedLiver injuryTumor Necrosis Factor-alphaGastroenterologyInterleukin-18NF-kappa BOrgan Sizemedicine.diseaseAdoptive TransferEndocrinologymedicine.anatomical_structureLiverApoptosisHepatocyteLymphocyte TransfusionCancer researchHepatocytesInterleukin 18Gut
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