0000000001063102

AUTHOR

Pierre-antoine Nocquet

showing 2 related works from this author

Total Synthesis of (±)-Scopolamine: Challenges of the Tropane Ring

2016

Scopolamine was synthesized using 6,7-dehydrotropine as a key intermediate. Rhodium-catalyzed [4 + 3] cycloaddition chemistry and a modified Robinson–Schopf reaction were each independently evaluated for their utility in constructing the tropane core. Both synthetic approaches gave comparable overall yields.

010405 organic chemistryChemistryStereochemistryOrganic ChemistryTotal synthesisTropane010402 general chemistryRing (chemistry)01 natural sciencesCycloaddition0104 chemical scienceschemistry.chemical_compoundScopolaminemedicineOrganic chemistryPhysical and Theoretical Chemistrymedicine.drugEuropean Journal of Organic Chemistry
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ChemInform Abstract: Total Synthesis of (.+-.)-Scopolamine: Challenges of the Tropane Ring.

2016

Scopolamine was synthesized using 6,7-dehydrotropine as a key intermediate. Rhodium-catalyzed [4 + 3] cycloaddition chemistry and a modified Robinson–Schopf reaction were each independently evaluated for their utility in constructing the tropane core. Both synthetic approaches gave comparable overall yields.

chemistry.chemical_compoundchemistryStereochemistryScopolaminemedicineTotal synthesisTropaneGeneral MedicineRing (chemistry)Cycloadditionmedicine.drugChemInform
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