LEMON-DERIVED EXTRACELLULAR VESICLES EXERT ANTI-INFLAMMATORY EFFECTS BY INHIBITING THE ERK/NF-KB PATHWAY

nflammation can be the leading cause of several diseases, including cancer, diabetes, and ulcerative colitis; however, the existing anti-inflammatory drugs cause side effects. For these reasons, it is necessary to find new supportive therapeutic agents. In recent years, plant-derived extracellular vesicles (PDEVs) are gaining increasing interest in the scientific community as they have been found to possess a variety of biological properties; among those, the anti-inflammatory effects have been described by different groups that evaluated the effects of PDEVs in in vitro and in vivo models. We successfully isolated and characterized extracellular vesicles from Citrus limon juice (LEVs) and …