0000000001067893
AUTHOR
M Gagliano
Effects of prenatal acute stress on the behavioural reactivity in handled and non-handled rat progeny
The effects of prenatal stress are dependent on the intensity and duration of the stress treatment: chronic, uncontrollable stress causes an impairment in the normal adaptive responses to physical and physiological stimuli whereas acute and mild stress facilitates the morphological development of fetal brain neurons. The presents study was designed to investigate whether a single stress exposure during pregnancy may exert a facilitatory effect on the behaviour of the juvenile progeny. The effects of a postnatal handling procedure have been also investigated. One-month prenatally stressed rats (PSR) whose dams had been restrained for 120 minutes at the 16th day of gestation, showed an increa…
Risposte endocrine ed immunitarie in calciatori professionisti dopo allenamento e competizione ufficiale
Effects of 8-OH-DPAT on open field performance of young and aged rats prenatally exposed to diazepam: a tool to rveal 5-HT1a receptor function
Central GABAergic and serotoninergic systems interact with one another and are implicated in controlling different behaviours. A gentle early long-lasting handling can prevent the deficits in locomotion and exploration in open field (O.F.) in 3-month-old male rats prenatally exposed to diazepam (DZ). Purpose of this study was to extend the research to older handled rats prenatally exposed to DZ and to assess the activity of 5-HT1A receptors (Rs), evaluating the performance in O.F. at 3 and 18 months of age following 8-OH-DPAT administration. A single daily s.c. injection of DZ (1.5 mg/kg) from gestation day 14 to gestation day 20 induced in aged, but not in young rats, a decrease in total d…