Author: Robert Fogel

0000000001070565

AUTHOR

Robert Fogel

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Pooled safety analysis of the fixed-dose combination of indacaterol and glycopyrronium (QVA149), its monocomponents, and tiotropium versus placebo in…

2014

BACKGROUND: To further assess the safety profile of the fixed-dose combination of indacaterol and glycopyrronium (QVA149) and its monocomponents; we investigated the impact of individual patient-level factors and time by integrating the patient-level safety data from the QVA149 clinical programme with relevant information from the independent indacaterol and glycopyrronium safety databases.METHODS: Data from 11,404 patients with chronic obstructive pulmonary disease (COPD) were pooled from 14 clinical studies of QVA149, indacaterol and glycopyrronium of ≥3 month's duration with at least two of the treatment groups: QVA149 110/50 μg, glycopyrronium 50 μg, indacaterol 150 μg, placebo or tiotr…

MalePulmonary and Respiratory Medicinemedicine.medical_specialtyFixed-dose combinationScopolamine DerivativesQuinolonesPlaceboPooled analysisPulmonary Disease Chronic ObstructiveRisk FactorsInternal medicinemedicineHumansTiotropium BromideIndacaterolAgedCOPDbusiness.industryTiotropiumHazard ratioQVA149Middle Agedmedicine.diseaseGlycopyrrolateConfidence intervalBronchodilator AgentsDrug CombinationsTreatment OutcomeAnesthesiaIndansIndacaterolDrug Therapy CombinationFemaleGlycopyrroniumSafetybusinessBody mass indexMacemedicine.drugRespiratory Medicine

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
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  - PE2_9 Electromagnetism
  - PE2_10Atomic, molecular physics
  - PE2_11Ultra-cold atoms and molecules
  - PE2_18Equilibrium and non-equilibrium statistical mechanics: steady states and dynamics
  - PE2_14Lasers, ultra-short lasers and laser physics
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  - PE2_13Quantum optics and quantum information
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LSLife Sciences
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SHSocial Sciences and Humanities
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