Author: Rania Allouche

0000000001070754

AUTHOR

Rania Allouche

0000-0003-1315-2743

showing 1 related works from this author

Optimized tableting for extremely oxygen-sensitive probiotics using direct compression

2018

International audience; Faecalibacterium prausnitzii was previously recognized for its intestinal anti-inflammatory activities and it has been shown less abundant in patients with chronic intestinal diseases. However, the main problems encountered in the use of this interesting anaerobic microorganism are firstly its high sensitivity to the oxygen and secondly, its ability to reach the large intestine alive as targeted site. The aim of this study was to investigate the effect of direct compression on the viability of this probiotic strain after different compression pressure and storage using three different excipients (MCC, HPMC and HPMCP). The effect of compression process on cell viabili…

0301 basic medicineTime FactorsCell SurvivalChemistry PharmaceuticalDrug Compounding[ SDV.AEN ] Life Sciences [q-bio]/Food and NutritionShear forceDirect compressionPharmaceutical ScienceFaecalibacterium prausnitziiStorage030226 pharmacology & pharmacylaw.inventionExcipients03 medical and health sciencesProbioticTableting0302 clinical medicinelaw[SDV.IDA]Life Sciences [q-bio]/Food engineeringPressureRelative humidity[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process EngineeringViability assayFood scienceF. prausnitziibiologyFaecalibacterium prausnitziiChemistryProbioticsTemperature[ SDV.IDA ] Life Sciences [q-bio]/Food engineeringHumidityCompression (physics)biology.organism_classificationOxygen030104 developmental biologyViabilityAnaerobic exercise[SDV.AEN]Life Sciences [q-bio]/Food and NutritionPre-consolidationTablets

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