Author: Sylvain Moineau

0000000001072121

AUTHOR

Sylvain Moineau

showing 2 related works from this author

Cooperation between Different CRISPR-Cas Types Enables Adaptation in an RNA-Targeting System

2021

CRISPR-Cas systems are immune systems that protect bacteria and archaea against their viruses, bacteriophages. Immunity is achieved through the acquisition of short DNA fragments from the viral invader’s genome.

bacteriophagesanimal diseasesvirusesevoluutiotype VIchemical and pharmacologic phenomenaadaptationFlavobacteriumMicrobiologybakteriofagitbakteeritClustered Regularly Interspaced Short Palindromic Repeatstype II1184 Genetics developmental biology physiologyDNAbiochemical phenomena metabolism and nutritionAdaptation PhysiologicalQR1-502immuunijärjestelmäCRISPRcoevolutionRNA ViralbacteriaRNAspacer acquisitionCRISPR-Cas Systemshorisontaalinen geeninsiirtoGenome BacterialResearch Article

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Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution.

2022

AbstractThe origin of viruses remains an open question. While lack of detectable sequence similarity hampers the analysis of distantly related viruses, structural biology investigations of conserved capsid protein structures facilitate the study of distant evolutionary relationships. Here we characterize the lipid-containing ssDNA temperate bacteriophage ΦCjT23, which infects Flavobacterium sp. (Bacteroidetes). We report ΦCjT23-like sequences in the genome of strains belonging to several Flavobacterium species. The virion structure determined by cryogenic electron microscopy reveals similarities to members of the viral kingdom Bamfordvirae that currently consists solely of dsDNA viruses wit…

/631/326/1321bacteriophagesviruksetcryoelectron microscopyevoluutioGeneral Physics and AstronomyelektronimikroskopiaDNA Single-Stranded/45/23FlavobacteriumGeneral Biochemistry Genetics and Molecular Biologybakteriofagit/631/45/535/1258/1259viral evolution/631/326/596/2554BacteriophagesMultidisciplinaryfylogenia/45fylogenetiikkaCryoelectron Microscopy/101/28articleGeneral Chemistryperimä1182 Biochemistry cell and molecular biologyCapsid Proteins

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PEPhysical Sciences and Engineering
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