Author: Evi Dietrich

0000000001074997

AUTHOR

Evi Dietrich

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Differential genetic determination of immune responsiveness to hepatitis B surface antigen and to hepatitis A virus: a vaccination study in twins.

2002

Summary Background The course of viral hepatitis is thought to be affected by genetic host variability and, in particular, by genes of the major histocompatibility locus. Hepatitis A and B vaccination is a useful model to study the effect of host factors on the immune response to viral antigens. We aimed to assess the heritability of the HBsAg (anti-HBs) and anti-hepatitis A virus (anti-HAV) immune response and to estimate the effect of the HLA-DRB1 locus and other genetic loci unlinked to HLA. Methods We did an open prospective study and vaccinated 202 twin pairs with a combined recombinant HBsAg/inactivated hepatitis A vaccine. We measured antibodies to HBsAg and HAV and determined HLA-DR…

AdultMaleHBsAgAdolescentHepatitis A vaccineHuman leukocyte antigenBiologyHepatitis A AntibodiesmedicineHumansHepatitis B VaccinesHepatitis B AntibodiesAgedGeneticsHepatitis B Surface AntigensVaccinationvirus diseasesHepatitis AGeneral MedicineHLA-DR AntigensHeritabilityMiddle Agedmedicine.diseasebiology.organism_classificationdigestive system diseasesRecombinant ProteinsImmunity ActiveHepadnaviridaeImmunologybiology.proteinTwin Studies as TopicFemaleHepatitis A virusAntibodyViral hepatitisHLA-DRB1 ChainsLancet (London, England)

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