0000000001077149
AUTHOR
V Martorana
showing 10 related works from this author
Fibrillogenesis of hen egg-white lysozyme at acidic pH
2009
SEVERE OSTEOPOROSIS AND MULTIPLE FRACTURES A CASE REPORT
2008
The authors present a clinical case of severe osteoporosis with periprothesic femoral fracture and numerous vertebral fractures in a 87 years old patient. Treatment had consist in reposition of prosthesis, fracture reduction with internal fixation plate. Teriparatide drug was administer as usual protocol. Clinical and X-rays controls after 3, 6 and 12 months showed a good result of therapy, with a healing fracture, a orthostatism and normal deambulation, with improvement of densimetry values and a less dorsolombar pain, as well as a significant improvement of patient’s quality of life
On the molecular structure of human neuroserpin polymers. Coagulation, fragmentation and latentization control serpin aggregation
2012
The polymerization of serpins is at the root of a large class of diseases; the molecular structure of serpin polymers has been recently debated. In this work, we study the polymerization kinetics of human neuroserpin by Fourier Transform Infra Red spectroscopy and by time-lapse Size Exclusion Chromatography. First, we show that two distinct neuroserpin polymers, formed at 45 and 85 °C, display the same isosbestic points in the Amide I band, and therefore share common secondary structure features. We also find a concentration independent polymerization rate at 45 °C suggesting that the polymerization rate limiting step is the formation of an activated monomeric species. The polymer structure…
Inactivation and polymerization of human neuroserpin
2010
Neuroserpin is an inhibitory enzyme, belonging to the family of serpins and involved in several pathologies, such as ischemia, Alzheimer disease, and FENIB (Familial Encephalopathy with Neuroserpin Inclusion Body). Here, we study the mechanism of neuroserpin inactivation and polymerization by different experimental techniques (static and dynamic light scattering, liquid chromatography, Fourier transform infrared spectroscopy, emission spectroscopy). Our results show that at intermediate temperatures (45-55 °C) neuroserpin forms flexible polymers with a size from a few tens to a few hundreds of nanometers. At high temperatures, above 80 °C, our results reveal a different polymeric form, reac…