0000000001079166

AUTHOR

Ch. Fottner

showing 1 related works from this author

Role of the insulin-like growth factor system in adrenocortical growth control and carcinogenesis.

2004

Clinically silent adrenocortical adenomas are the most frequent abnormalities in the adrenal gland. In contrast, adrenocortical carcinoma is a rare tumor with an extremely poor prognosis. The factors responsible for the frequent occurrence of benign adrenocortical tumors on one hand and the rare malignant transformation on the other are not known. Several genetic alterations such as loss of imprinting or loss of heterozygosity of the 11p15 gene locus causing a strong IGF-II overexpression have been demonstrated in the majority of adrenocortical carcinomas. In addition to IGF-II overexpression, increased levels of the IGF-I-receptor and IGFBP-2 have been found in advanced human adrenocortica…

Genetically modified mousemedicine.medical_specialtyEndocrinology Diabetes and Metabolismmedicine.medical_treatmentClinical BiochemistryAdrenal Gland NeoplasmsLoss of HeterozygosityBiologymedicine.disease_causeBiochemistryMalignant transformationReceptor IGF Type 1Loss of heterozygosityInsulin-like growth factorMiceEndocrinologyInsulin-Like Growth Factor IIInternal medicineCell Line TumormedicineAdrenocortical carcinomaAnimalsHumansNeoplastic transformationNeoplastic ProcessesAdrenal glandChromosomes Human Pair 11Biochemistry (medical)CarcinomaGeneral Medicinemedicine.diseaseGene Expression Regulation NeoplasticInsulin-Like Growth Factor Binding Protein 2medicine.anatomical_structureEndocrinologyCarcinogenesisSignal TransductionHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
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