0000000001079567
AUTHOR
G. Villa
The X-ray gas scintillation spectrometer experiment on the first spacelab flight
The First Spacelab mission, launched on Space ShuttleFlight STS-9 in November 1983 carried a multidisciplinary payload which was intended to demonstrate that valuable scientific results can be achieved from such short duration missions. The payload complement included a spectrometer to undertake observations of the brighter cosmic X-ray sources. The primary scientific objectives of this experiment were the study of detailed spectral features in cosmic X-ray sources and their associated temporal variations over a wide energy range from about 2 up to 30 keV. The instrument based on the gas scintillation proportional counter had an effective area of some 180 cm2 with an energy resolution of ∼9…
The optical/UV filters for the EPIC experiment
EPIC, the European Photon Imaging Cameras is an experiment based on cooled CCDs on board the ESA X-ray Multi Mirrors satellite due to be launched in 1999. Since CCD's are sensitive to radiation other than X-rays, namely Optical and UV light, filters are necessary to prevent this radiation from reaching the detector sensitive area. Three types of filters were developed, to be used alternatively depending on target source. Here we report on the medium and thin filters developed by MOXTEK Inc. in Orem, Utah, while the thick ones, developed at the Max-Planck-Institut fur Extraterrestrische Physik (MPE, Germany) have been described elsewhere. The two filters, described here, have a 1600 /spl Ari…
The Gas Scintillation Proportional Counter on EXOSAT
The inclusion of a gas scintillation proportional counter (GSPC) within the EXOSAT payload complement significantly improves the spectroscopic capability of the mission. This broad-band medium energy spectrometer used in conjunction with the large area proportioni counter array (ME) should provide additional spectroscopic details on strong X-ray sources at photon energies above ~ 2 keV. The novel type of detector has an energy resolution at least a factor of two better than the ME experiment over a similar bandwidth (2 – 40 keV).
Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: Lessons from the DALI Study
The aims of this study were to describe the variability in protein binding of teicoplanin in critically ill patients as well as the number of patients achieving therapeutic target concentrations. This report is part of the multinational pharmacokinetic DALI Study. Patients were sampled on a single day, with blood samples taken both at the midpoint and the end of the dosing interval. Total and unbound teicoplanin concentrations were assayed using validated chromatographic methods. The lower therapeutic range of teicoplanin was defined as total trough concentrations from 10 to 20 mg/L and the higher range as 10-30 mg/L. Thirteen critically ill patients were available for analysis. The followi…
The European Photon Imaging Camera on XMM-Newton: The MOS Cameras
The EPIC focal plane imaging spectrometers on XMM-Newton use CCDs to record the images and spectra of celestial X-ray sources focused by the three X-ray mirrors. There is one camera at the focus of each mirror; two of the cameras contain seven MOS CCDs, while the third uses twelve PN CCDs, defining a circular field of view of 30 arcmin diameter in each case. The CCDs were specially developed for EPIC, and combine high quality imaging with spectral resolution close to the Fano limit. A filter wheel carrying three kinds of X-ray transparent light blocking filter, a fully closed, and a fully open position, is fitted to each EPIC instrument. The CCDs are cooled passively and are under full clos…