0000000001083757
AUTHOR
V. Morra
Effects of immunomodulatory treatment with subcutaneous interferon beta-1a on cognitive decline in mildly disabled patients with relapsing-remitting multiple sclerosis
The objective of this study was to assess the effects of subcutaneous (sc) interferon beta-1a (IFNβ-1a) on cognition in mildly disabled patients with relapsing—remitting multiple sclerosis (RRMS). Patients aged 18—50 years with RRMS (McDonald criteria; Expanded Disability Status Scale score ≤4.0) were assigned IFNβ therapy at the physician’s discretion and underwent standardized magnetic resonance imaging, neurological examination and neuropsychological testing at the baseline and regular intervals for up to three years. This analysis included 459 patients who received sc IFNβ-1a (44 mcg: n = 236; 22 mcg: n = 223; three-year follow up was available for 318 patients). The hazard ratio for c…
Perforazione della Caldera dei Campi Flegrei - Una proposta anfibia IODP-ICDP
Active calderas are major volcanic features of the Earth’s crust associated with shallow magma reservoirs, high geothermal gradients, and geodynamic unrests often documented through historical time. As large caldera-forming eruptions are also among the most catastrophic events that may affect the Earth’s surface, calderas are ostensibly the sites of major interest for both the scientific community and governmental institutions worldwide. The Campi Flegrei is an active volcanic area located west of the city of Naples, largely on the continental shelf of the Eastern Tyrrhenian margin that has been characterized by dominantly explosive eruptions during the latest Quaternary. This is one among …