0000000001083861

AUTHOR

S. Spada

showing 3 related works from this author

5-Fluorouracil plus interferon α-2a compared to 5-fluorouracil alone in the treatment of advanced colon carcinoma: A multicentric randomized study

1998

Biochemical modulation is one of the most interesting fields in cancer chemotherapy. Interferon-alpha (IFNalpha) is a cytokine that is able to influence the pharmacodynamics of 5-fluorouracil (5FU) through a number of mechanisms. With the aim of confirming some data emerging from the literature, we initiated a multicentric randomized study comparing the combination of 5FU and IFNalpha-2a with 5FU alone in the treatment of advanced or metastatic colon cancer. A group of 205 colon cancer patients (104 in the 5FU arm and 101 in the 5FU + IFNapha-2a arm) were included in the final intention-to-treat analysis. Rectal cancers were not considered eligible. All patients had measurable disease, were…

MaleAntimetabolites AntineoplasticCancer Researchmedicine.medical_specialtyColorectal cancerAlpha interferonInterferon alpha-2GastroenterologyMetastasisInternal medicineAntineoplastic Combined Chemotherapy ProtocolsmedicineCarcinomaHumansInterferon alfaAgedLeukopeniabusiness.industryStandard treatmentInterferon-alphaGeneral MedicineMiddle Agedmedicine.diseaseRecombinant ProteinsSurgeryOncologyFluorouracilColonic NeoplasmsFemaleFluorouracilmedicine.symptombusinessmedicine.drugJournal of Cancer Research and Clinical Oncology
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“Weekly docetaxel and gemcitabine as first line treatment for metastatic breast cancer: results of a multicenter phase II study”

2004

<i>Objectives:</i> We conducted a multicenter phase II study to evaluate the clinical efficacy, toxicity, and dose intensity of a new weekly schedule of docetaxel and gemcitabine as first-line treatment of metastatic breast cancer patients. <i>Methods:</i> We enrolled 58 patients, 52% of whom had received a previous anthracycline-containing chemotherapy. The treatment schedule was: docetaxel 35 mg/m<sup>2</sup> and gemcitabine 800 mg/m<sup>2</sup> i.v. on days 1, 8, 15 every 28 days. <i>Results:</i> All patients were assessable for toxicity and 56 for efficacy. Overall response rate was 64.3% with 16.1% of complete responses and 48…

OncologyAdultCancer Researchmedicine.medical_specialtyMaximum Tolerated Dosemedicine.drug_classPhases of clinical researchBreast NeoplasmsDocetaxelAntimetaboliteDeoxycytidineMetastasisBreast cancerInternal medicineAntineoplastic Combined Chemotherapy ProtocolsMedicineHumansAgedNeoplasm Stagingbusiness.industryCarcinoma Ductal BreastGeneral MedicineMiddle Agedmedicine.diseaseMetastatic breast cancerGemcitabineGemcitabineSurgerySurvival RateCarcinoma LobularTreatment OutcomeOncologyDocetaxelCarcinoma MedullaryToxicityFemaleTaxoidsbusinessmedicine.drug
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Children with special health care needs attending emergency department in Italy: analysis of 3479 cases

2020

Abstract Background Although children with special health care needs (CSHCN) represent a minority of the population, they go through more hospitalizations, more admissions to the Emergency Department (ED), and receive a major number of medical prescriptions, in comparison to general pediatric population. Objectives of the study were to determine the reasons for admission to the ED in Italian CSHCN, and to describe the association between patient’s demographic data, clinical history, and health services requirements. Methods Ad hoc web site was created to collect retrospective data of 3479 visits of CSHCN to the ED in 58 Italian Hospitals. Results Seventy-two percent of patients admitted to …

MaleMetabolic diseaseHospitalization rateCongenital skeletal conditionHospitalization rateChildren with special health care needs; Congenital skeletal condition; Emergency department; Hospitalization rate; Isolated CNS malformation; Metabolic diseases; Multiple AED therapy; Neuromuscular diseases; Syndromic disorders; True isolated microcephaly0302 clinical medicineClinical historyMedicineChildeducation.field_of_studyNeuromuscular diseaseSettore MED/38Disabled ChildrenHospitalizationNeuromuscular diseasesSettore MED/38 - PEDIATRIA GENERALE E SPECIALISTICAItalyChild PreschoolFemaleChildren with special health care needEmergency Service Hospitalmedicine.medical_specialtyAdolescentPopulationTriage CodeChildren with special health care needsSyndromic disordersChildren with special health care needs03 medical and health sciencesPharmacotherapy030225 pediatricsHumansMedical prescriptioneducationRetrospective StudiesHealth Services Needs and DemandSyndromic disorderEmergency departmentTrue isolated microcephalybusiness.industryResearchInfant NewbornInfantMetabolic diseases030208 emergency & critical care medicineEmergency departmentChildren with special health care needs Congenital skeletal conditionsEmergency department Hospitalization rate Isolated CNS malformation Metabolic diseases Multiple AED therapy Neuromuscular diseases Syndromic disorders True isolated microcephalyFamily medicineChronic DiseaseMultiple AED therapyIsolated CNS malformationbusinessFacilities and Services UtilizationItalian Journal of Pediatrics
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