IPOVITAMINOSI D ED EFFETTI BENEFICI DELLA TERAPIA SOSTITUTIVA CON GH SUI LIVELLI DI VITAMINA D IN BAMBINI AFFETTI DA DEFICIT DI GH

Metabolic effects of GH therapy in adults with GH deficiency: a 2 year prospective study

Background Growth hormone deficiency (GHD) in adults is associated with adverse metabolic profile, while data about the metabolic effects of GH treatment are controversial. Aim To evaluate the metabolic influence of GH replacement in GHD. Subjects and Methods Data of 65 patients (35 M, age 54 ± 18 yrs) were analyzed. Before GH therapy and yearly up to 2 years we measured BMI, WC, visceral adiposity index (VAI), IGF-1, lipide profile, HbA1c and basal insulin-secretion (Homa-β) and -sensitivity (Homa-IR) indexes. Results No subject showed overt dysglycemia at baseline and during GH therapy. Hypertriglyceridemia was detected in 36 patients at baseline and in 31 and 20 respectively at 12 and 24…

LONG-TERM METABOLIC EFFECTS OF GH THERAPY IN CHILDREN WITH IDIOPATHIC GH DEFICIENCY

Background Increased insulin levels during GH replacement therapy are often reported both in adults and in children with GH deficiency (GHD), although discordant data fully describe the behavior of metabolic parameters during GH therapy in children and overall the majority of published data are limited to the first 12 months of follow-up and in small populations. Aim To evaluate the long-term metabolic influences of GH replacement in a large selected cohort of prepubertal children with idiopathic GHD during GH therapy. Subjects and Methods Data of 194 prepubertal GHD children (150 M, 44 F; age 10.85 ± 2.77 yrs) were analyzed. Before GH therapy and yearly up to 36 months we measured body mas…