0000000001088389
AUTHOR
Harvey Checkoway
A glossary for research in occupational health.
This glossary includes a selection of terms pertaining to the field of research in occupational health. The glossary is mostly addressed to readers not familiarised with the more specific terms used in the study and protection of workers' health. The terms have been ordered according to their logical connections, so the glossary can be read from beginning to end giving the reader an overview on occupational health research main focuses, methods, and applications.
Large-scale replication and heterogeneity in Parkinson disease genetic loci
Objective: Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which these genetic effects are consistent across different populations is unknown. Methods: Investigators from the Genetic Epidemiology of Parkinson9s Disease Consortium were invited to participate in the study. A total of 11 SNPs were genotyped in 8,750 cases and 8,955 controls. Fixed as well as random effects models were used to provide the summary risk estimates for these variants. We evaluated between-study heterogeneity and heterogeneity between populations of different ances…