0000000001088867

AUTHOR

Filippo Castiglione

showing 3 related works from this author

An Early Stage Researcher's Primer on Systems Medicine Terminology

2021

Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diametral different fields, including medicine, biology, statistics, modeling and simulation, and data science. Such heterogeneity leads to semantic issues, which may slow down implementation and fruitful interaction between these highly diverse fields. Methods: In this review, we collect and explain more than100 terms related to Systems Medicine. Thes…

computer_scienceGraphs and NetworksmedicineGlossary[SDV]Life Sciences [q-bio]Comprehensive ReviewTerminology03 medical and health sciences0302 clinical medicineSDG 3 - Good Health and Well-beingMachine learningGeneticsmultiscale data science[INFO]Computer Science [cs]systems medicinemulti-scale modellingMulti-scale modellingComputingMilieux_MISCELLANEOUS030304 developmental biologyInterdisciplinarityMulti-scale data science0303 health scienceshealthGeneral MedicineHuman bodySciences bio-médicales et agricolesData science[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]multiscale modeling3. Good healthTerm (time)Systems medicinemachine learningmulti-scale data scienceSystems medicineMedicine/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being030217 neurology & neurosurgeryNetwork and Systems Medicine
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Mechanistic Modeling and Multiscale Applications for Precision Medicine: Theory and Practice

2020

Drug research, therapy development, and other areas of pharmacology and medicine can benefit from simula- tions and optimization of mathematical models that contain a mathematical description of interactions between systems elements at the cellular, tissue, organ, body, and population level. This approach is the foundation of systems medicine and precision medicine. Here, simulated experiments are performed with computers (in silico) first, and they are then replicated through lab experiments (in vivo or in vitro) or clinical studies. In turn, these experiments and studies can be used to validate or improve the models. This iterative loop of dry and wet lab work is successful when biomedica…

medicinemultiscaleMathematical modelManagement scienceComputer sciencefungifood and beveragesmodelingGeneral MedicinePrecision medicineMultiscale modelingNetwork and Systems Medicine
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Transconjunctival sutureless 25-Gauge versus 20-Gauge standard vitrectomy: correlation between corneal topography and ultrasound biomicroscopy measur…

2009

Purpose: To determine the correlation between corneal shape changes and ultrasound biomicroscopy (UBM) findings at the sclerotomy sites in conventional 20-gauge (G) pars plana vitrectomy (PPV) and 25-G transconjunctival sutureless vitrectomy (TSV) and to compare the effectiveness of the two surgical methods. Design: Prospective, comparative, observational case series. Methods: Sixty consecutive eyes (60 patients) undergoing primary 3-port PPV. Thirty eyes (30 patients, group 20-G) were treated with 20-G standard PPV and 30 eyes (30 patients, group 25-G) with 25-G TSV. We compared healing of the sclerotomy sites in the two groups. We determined the correlation between corneal shape changes (…

Pars planaAdultMalemedicine.medical_specialtyMicrosurgerygenetic structuresmedicine.medical_treatmentUltrasound biomicroscopyMicroscopy AcousticVitrectomyAstigmatismUltrasound biomicroscopyCorneaPostoperative ComplicationsCorneaOphthalmologyVitrectomySuture TechniquemedicineHumansProspective StudiesDioptreAgedWound Healingmedicine.diagnostic_testbusiness.industrySuture TechniquesAstigmatismCorneal TopographyMiddle AgedCorneal topographymedicine.diseaseCorneal shape changeeye diseasesSclera25-gauge transconjunctival sutureless vitrectomyOphthalmologyProspective Studiemedicine.anatomical_structureSclerostomyFemalesense organs20-gauge pars plana vitrectomybusinessConjunctivaScleraHuman
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