Diffusion in slice preparations bathed in unstirred solutions

1987

A diffusion model is described here, which allows for the estimations of drug concentration changes in porous media, such as in slice tissues of the central nervous system (CNS) bathed in unstirred solutions following abrupt changes of drug concentration. This model may be used for the interpretation of data obtained in neuropharmacological studies if (i) the diffusion coefficient of the molecules under investigation is constant within the excised tissue, (ii) drug molecules are diffusing only in the extracellular space (ECS) and are not bound by the tissue, (iii) drug molecules diffuse mainly within one dimension, (iv) the drug concentration in the bath is changed within 5 s, and (v) the b…