0000000001091127

AUTHOR

I. Pibiri

showing 18 related works from this author

Synthesis of Fluorinated Bent-Core Mesogens (BCMs) Containing the 1,2,4-Oxadiazole Ring

2015

New fluorinated bent-core mesogens containing the 1,2,4-oxadiazole or 1,2,4-triazole nucleus have been synthesized taking advantage of the ANRORC (Addition of Nucleophile, Ring-Opening, Ring-Closure) reactivity of 5-perfluoroalkyl-1,2,4-oxadiazoles. Physical state changes of the obtained compounds were characterized through DSC, POM, and SAXS. Besides the formation of a smectic mesophase, a novel behavior as organic molecular glass was evidenced for some 1,2,4-oxadiazole derivatives.

Oxadiazole Fluorinated materials triazole Liquid crystalsSettore CHIM/06 - Chimica Organica
researchProduct

Integrated computational and experimental approaches for the identification of new molecules with readthrough activity on premature termination codon…

2015

cystic fibrosiscomputational approaches; readthrough; premature stop codon; cystic fibrosisreadthroughpremature stop codoncomputational approache
researchProduct

Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells

2016

readthrough; premature stop codons; PTC; cystic fibrosis; novel moleculesnovel moleculesPTCreadthroughpremature stop codoncystic fibrosi
researchProduct

Readthrough Inducing Drugs (TRIDs) in human fibroblasts harboring the c.5047 C>T (R1683*) nonsense mutation

2022

Settore BIO/18 - GeneticaNonse mutationTRIDsreadthroughSettore BIO/11 - Biologia MolecolareLRBAoxadiazole
researchProduct

Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution evaluation in mice models

nonsense mutationSettore CHIM/06 - Chimica OrganicaTRIDReadthrough
researchProduct

Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells

2017

Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells Laura Lentini, Raffaella Melfi, Sara Baldassano, Marco Tutone, Aldo Di Leonardo, Andrea Pace, Ivana Pibiri Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo Background and rationale Cystic Fibrosis patients with nonsense mutations in the CFTR gene have a more severe form of the disease. Nonsense mutations represent about 10% of the mutations that affect the CFTR gene and they are frequently associated to the classical F508 mutation (1). A potential treatment for this genetic alteration is to promote the translationa…

Settore BIO/18 - Genetica-Fluorinated heterocycles -Nonsense Mutations -Premature stop codon -ReadthroughSettore BIO/11 - Biologia MolecolareSettore CHIM/06 - Chimica OrganicaSettore BIO/09 - FisiologiaSettore CHIM/08 - Chimica Farmaceutica
researchProduct

CCDC 633320: Experimental Crystal Structure Determination

2008

Related Article: A.P.Piccionello, I.Pibiri, A.Pace, R.A.Raccuglia, S.Buscemi, N.Vivona, G.Giorgi|2007|Heterocycles|71|1529|doi:10.3987/COM-07-11040

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(Z)-N-((2233-tetramethylaziridin-1-yl)(phenyl)methylene)benzamideExperimental 3D Coordinates
researchProduct

CCDC 633321: Experimental Crystal Structure Determination

2008

Related Article: A.P.Piccionello, I.Pibiri, A.Pace, R.A.Raccuglia, S.Buscemi, N.Vivona, G.Giorgi|2007|Heterocycles|71|1529|doi:10.3987/COM-07-11040

Space GroupCrystallographyCrystal System(Z)-N-((23-dimethylbut-3-en-2-ylamino)(phenyl)methylene)benzamideCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 630243: Experimental Crystal Structure Determination

2007

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, I.Pibiri, N.Vivona, G.Giorgi, A.Mazzanti, D.Spinelli|2006|J.Org.Chem.|71|8106|doi:10.1021/jo061251e

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters3-(Pentadecafluoroheptyl)-1-methyl-5-phenyl-1H-(124)-triazoleExperimental 3D Coordinates
researchProduct

CCDC 915396: Experimental Crystal Structure Determination

2013

Related Article: M.Saccone,G.Cavallo,P.Metrangolo,A.Pace,I.Pibiri,T.Pilati,G.Resnati,G.Terraneo|2013|CrystEngComm|15|3102|doi:10.1039/C3CE40268A

Space GroupCrystallography11223344-Octafluoro-14-diiodobutane 44'-(124-oxadiazole-35-diyl)dipyridineCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 251468: Experimental Crystal Structure Determination

2004

Related Article: J.R.Hanson, P.B.Hitchcock, I.Pibiri, F.Piozzi|2003|J.Chem.Res.||147|doi:10.3184/030823403103173291

Space GroupCrystallographyCrystal SystemCrystal Structure12alpha-HydroxyrosenonolactoneCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 630242: Experimental Crystal Structure Determination

2007

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, I.Pibiri, N.Vivona, G.Giorgi, A.Mazzanti, D.Spinelli|2006|J.Org.Chem.|71|8106|doi:10.1021/jo061251e

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN^1^-Methyl-5-hydroxylimino-3-pentadecafluoroheptyl-124-triazin-6-one ethanol solvateExperimental 3D Coordinates
researchProduct

CCDC 245638: Experimental Crystal Structure Determination

2004

Related Article: A.Pace, I.Pibiri, S.Buscemi, N.Vivona, L.Malpezzi|2004|J.Org.Chem.|69|4108|doi:10.1021/jo049814e

Space GroupCrystallography1-Methyl-3-N-methylamino-5-pentadecafluoroheptyl-124-triazoleCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 251467: Experimental Crystal Structure Determination

2004

Related Article: J.R.Hanson, P.B.Hitchcock, I.Pibiri, F.Piozzi|2003|J.Chem.Res.||147|doi:10.3184/030823403103173291

Space GroupCrystallography6beta-HydroxyrosenonolactoneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 245639: Experimental Crystal Structure Determination

2004

Related Article: A.Pace, I.Pibiri, S.Buscemi, N.Vivona, L.Malpezzi|2004|J.Org.Chem.|69|4108|doi:10.1021/jo049814e

Space GroupCrystallographyCrystal System2-N-Methylamino-5-trifluoromethyl-134-oxadiazoleCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 915397: Experimental Crystal Structure Determination

2013

Related Article: M.Saccone,G.Cavallo,P.Metrangolo,A.Pace,I.Pibiri,T.Pilati,G.Resnati,G.Terraneo|2013|CrystEngComm|15|3102|doi:10.1039/C3CE40268A

112233445566-Dodecafluoro-16-diiodohexane 44'-(124-oxadiazole-35-diyl)dipyridineSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 630241: Experimental Crystal Structure Determination

2007

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, I.Pibiri, N.Vivona, G.Giorgi, A.Mazzanti, D.Spinelli|2006|J.Org.Chem.|71|8106|doi:10.1021/jo061251e

Space GroupCrystallographyCrystal SystemCrystal StructureNO-Dibenzoyl-5-hydroxylamino-3-heptafluoropropyl-124-triazin-6-oneCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 251469: Experimental Crystal Structure Determination

2004

Related Article: J.R.Hanson, P.B.Hitchcock, I.Pibiri, F.Piozzi|2003|J.Chem.Res.||147|doi:10.3184/030823403103173291

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates15S16-Dihydroxyrosenonolactone monohydrate
researchProduct