0000000001098589

AUTHOR

Lucio Santoro

showing 2 related works from this author

Monitoring effectiveness and safety of Tafamidis in transthyretin amyloidosis in Italy: a longitudinal multicenter study in a non-endemic area

2016

Tafamidis is a transthyretin (TTR) stabilizer able to prevent TTR tetramer dissociation. There have been a few encouraging studies on Tafamidis efficacy in early-onset inherited transthyretin amyloidosis (ATTR) due to Val30Met mutation. However, less is known about its efficacy in later disease stages and in non-Val30Met mutations. We performed a multi-center observational study on symptomatic ATTR patients prescribed to receive Tafamidis. We followed up patients according to a standardized protocol including general medical, cardiological and neurological assessments at baseline and every 6 months up to 3 years. Sixty-one (42 males) patients were recruited. Only 28 % of enrolled subjects h…

MaleTafamidisAmyloid polyneuropathyNeurologyCardiomyopathyDisease030204 cardiovascular system & hematologySeverity of Illness IndexTransthyretinchemistry.chemical_compound0302 clinical medicinePrealbuminTafamidiLongitudinal StudiesStage (cooking)Aged 80 and overBenzoxazolesbiologyAmyloidosisMiddle Agedamyloid polyneuropathy; tafamidis; transthyretinPrognosisTafamidisSettore MED/26 - NEUROLOGIATreatment OutcomeItalyNeurologyDisease ProgressionFemaleAmyloid polyneuropathy; Tafamidis; Transthyretin; Neurology (clinical); NeurologyAdultmedicine.medical_specialty03 medical and health sciencesInternal medicineSeverity of illnessmedicineHumansAgedAmyloid Neuropathies Familialbusiness.industrynutritional and metabolic diseasesmedicine.diseaseSurgeryTransthyretinchemistryMutationbiology.proteinNeurology (clinical)business030217 neurology & neurosurgeryFollow-Up StudiesJournal of Neurology
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Risk factors for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): antecedent events, lifestyle and dietary habits. Data from the Ita…

2020

Background and purpose: The role of lifestyle and dietary habits and antecedent events has not been clearly identified in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Methods: Information was collected about modifiable environmental factors and antecedent infections and vaccinations in patients with CIDP included in an Italian CIDP Database. Only patients who reported not having changed their diet or the lifestyle habits investigated in the study after the appearance of CIDP were included. The partners of patients with CIDP were chosen as controls. Gender-matched analysis was performed with randomly selected controls with a 1:1 ratio of patients and controls. Results: D…

AdultMalemedicine.medical_specialtylifestyleDatabases FactualDiseasecomputer.software_genreSettore MED/26chronic inflammatory demyelinating neuropathy; chronic inflammatory demyelinating polyradiculoneuropathy; diet; epidemiology; infections; lifestyle; vaccination03 medical and health sciences0302 clinical medicineRisk FactorsEpidemiologymedicineHumans030212 general & internal medicineinfectionsRisk factorChildLife Stylechronic inflammatory demyelinating polyradiculoneuropathyDatabasebusiness.industryAntecedent variablechronic inflammatory demyelinating neuropathyPolyradiculoneuropathyFeeding BehaviorMiddle Agedmedicine.diseasevaccinationinfectionSettore MED/26 - NEUROLOGIAAntecedent (behavioral psychology)ItalyPolyradiculoneuropathy Chronic Inflammatory DemyelinatingNeurologyFemaleepidemiologyNeurology (clinical)ComplicationbusinessLifestyle habitsdietcomputer030217 neurology & neurosurgery
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