0000000001099151

AUTHOR

Marc Dumas

showing 2 related works from this author

Cemiplimab for locally advanced and metastatic cutaneous squamous-cell carcinomas: Real-life experience from the French CAREPI study group

2021

Although cemiplimab has been approved for locally advanced (la) and metastatic (m) cutaneous squamous-cell carcinomas (CSCCs), its real-life value has not yet been demonstrated. An early-access program enrolled patients with la/mCSCCs to receive cemiplimab. Endpoints were best overall response rate (BOR), progression-free survival (PFS), overall survival (OS), duration of response (DOR) and safety. The 245 patients (mean age 77 years, 73% male, 49% prior systemic treatment, 24% immunocompromised, 27% Eastern Cooperative Oncology Group performance status (PS) ≥ 2) had laCSCCs (35%) or mCSCCs (65%). For the 240 recipients of ≥1 infusion(s), the BOR was 50.4% (complete, 21%

Cancer Researchmedicine.medical_specialtycutaneous squamous cell carcinomaLocally advancedBest Overall Response[SDV.CAN]Life Sciences [q-bio]/CancerGastroenterologyArticle030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineInternal medicineOverall survivalMedicineAdverse effectGroup performanceRC254-282Immune statusbusiness.industryNeoplasms. Tumors. Oncology. Including cancer and carcinogensMean agemedicine.diseasechronic dermatosisToxic epidermal necrolysis3. Good healthimmunocompromisedreal-life settingOncology030220 oncology & carcinogenesisPD-1–blocking antibodycemiplimabbusiness[SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
researchProduct

Safety improvement of a simple colorimetric determination of meprobamate in serum or urine

1999

National audience; Les intoxications par le méprobamate sont relativement moins fréquentes que les intoxications par benzodiazépines, mais elles sont généralement beaucoup plus graves. Les méthodes de dosages ne recourant pas à la chromatographie en phase gazeuse sont peu nombreuses et délicates. Nous décrivons ici une adaptation de la technique colorimétrique de Ludwig et Hoffmann pour doser le méprobamate sérique. Dans cette technique, le benzène peut être avantageusement remplacé par le toluène dont la toxicité médullaire est beaucoup plus faible

[ SDE ] Environmental Sciences[SDE] Environmental Sciences
researchProduct