0000000001100223
AUTHOR
R Fazio
INFLUENZA DEL DIAMETRO DEL FORO SUL COMPORTAMENTO IN COMPRESSIONE DI COLONNE IN C.A.
Core-drilling technique is nowadays always more frequently performed in existing reinforced concrete (RC) structures in order to investigate on the mechanical properties of concrete and for structural health monitoring purposes. Even if the engineering practice discourages to drill columns, this can be often unavoidable. In this last case the presence of the circular opening influences the compressive behavior of the column in terms of load-carrying capacity and axial deformability. The goal of this investigation was the experimental evaluation of the effects induced by circular openings on the behavior of RC columns. 24 reinforced and plain concrete prisms in presence of circular openings …
Erythropoietin in amyotrophic lateral sclerosis: a multicentre, randomized, double blind, placebo controlled, phase III study.
Objective To assess the efficacy of recombinant human erythropoietin (rhEPO) in amyotrophic lateral sclerosis (ALS). Methods Patients with probable laboratory-supported, probable or definite ALS were enrolled by 25 Italian centres and randomly assigned (1:1) to receive intravenous rhEPO 40 000 IU or placebo fortnightly as add-on treatment to riluzole 100 mg daily for 12 months. The primary composite outcome was survival, tracheotomy or >23 h non-invasive ventilation (NIV). Secondary outcomes were ALSFRS-R, slow vital capacity (sVC) and quality of life (ALSAQ-40) decline. Tolerability was evaluated analysing adverse events (AEs) causing withdrawal. The randomisation sequence was computer-…