0000000001100337
AUTHOR
V. Spina
Polyphased mesozoic rifting from the Atlas to the north-west Africa paleomargin
24 pages; International audience; Based on the interpretation of geological maps, seismic reflection and well data complemented with a bibliographic compilation and field work in the Rif, we investigate the factors that control the rift initiation, its development and the formation of oceanic crust in NW Africa. From SE to NW, we examine the Western Sahara Atlas, the Tendrara, the Guercif, and the Rif basins, to establish their geodynamic evolution in relation with the Mesozoic formation of the Central Atlantic and Maghrebian Tethys oceans, respectively. The Triassic extension was diffuse and developed over Lower Carboniferous horst-and-graben structures formed in the NW passive margin of G…
A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome
Richter syndrome (RS) represents the transformation of chronic lymphocytic leukaemia (CLL) to aggressive lymphoma. Risk factors of CLL transformation to RS are only partly known. We explored the role of the host genetic background as a risk factor for RS occurrence. Forty-five single nucleotide polimorphisms (SNPs) known to be relevant for CLL prognosis were genotyped in a consecutive cohort of 331 CLL, of which 21 had transformed to RS. After correcting for multiple testing and adjusting for previously reported RS risk factors, the LRP4 rs2306029 TT variant genotype was the sole SNP independently associated with a higher risk of RS transformation (Hazard Ratio: 4·17; P = 0·001; q = 0·047).…