0000000001102558

AUTHOR

Francisco J. Martín Fernández

showing 2 related works from this author

Insights into the inhibited form of the redox-sensitive SufE-like sulfur acceptor CsdE

2017

17 p.-8 fig.

0301 basic medicineProtein ConformationDimerlcsh:MedicineMolecular DynamicsCrystallography X-RayPhysical ChemistryBiochemistryDEAD-box RNA HelicasesMolecular dynamicschemistry.chemical_compoundComputational ChemistryNucleophileBiochemical Simulationslcsh:ScienceMultidisciplinaryCrystallographyChemistryOrganic CompoundsPhysicsEscherichia coli ProteinsCondensed Matter Physics3. Good healthPhysical sciencesChemistryCarbon-Sulfur LyasesBiochemistryCrystal StructureResearch ArticleChemical ElementsProtein subunitChemical physicschemistry.chemical_elementOxidative phosphorylationMolecular Dynamics Simulation03 medical and health sciencesThiolsEscherichia coliSolid State PhysicsProtein Interaction Domains and MotifsChemical BondingOrganic Chemistrylcsh:RChemical CompoundsBiology and Life SciencesComputational BiologyDimers (Chemical physics)Hydrogen BondingCell BiologySulfurAcceptorRedox sensitiveOxidative Stress030104 developmental biologyBiophysicslcsh:QProtein MultimerizationSulfur
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Double-blind, randomized, placebo-controlled trial of allergen-specific immunotherapy with the major allergen Alt a1

2019

Background: There have been few studies conducted on the efficacy and safety of specific immunotherapy with allergen extracts of fungi compared with other allergen extracts, and there are no data on the major allergen Alt a 1 of the fungus Alternaria alternata. Objectives: We sought to evaluate the efficacy and safety of subcutaneous immunotherapy with 2 different doses of Alt a 1 in patients with rhinoconjunctivitis caused by sensitization to A alternata. Method: We performed a multicenter, randomized, double-blind, placebo-controlled trial with Alt a 1 administered subcutaneously in patients with allergic rhinoconjunctivitis with or without controlled asthma aged 12 to 65 years. Three gro…

AdultMalesafetyAllergymedicine.medical_specialtyAllergen immunotherapyAl·lèrgiaAdolescentImmunologyefficacyPlacebo-controlled studyPlacebomedicine.disease_causeFungal ProteinsYoung AdultAllergenDouble-Blind Methodchildrensubcutaneous immunotherapyInternal medicinemedicineadultsImmunology and AllergyHumansmolecular immunotherapyAdverse effectChildAgedConjunctivitis AllergicAllergen immunotherapyIntention-to-treat analysisbusiness.industryrhinoconjunctivitisclinical trialAllergensImmunoglobulin EMiddle Agedmedicine.diseaseAsthmaClinical trialfungal allergyDesensitization ImmunologicImmunoglobulin GAlt a 1Femalebusinesspurified allergen
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