0000000001102951

AUTHOR

Friederike Siebelt

showing 2 related works from this author

NF-ATp plays a prominent role in the transcriptional induction of Th2-type lymphokines

1997

Antigens Differentiation T-LymphocyteCD4-Positive T-LymphocytesTranscription GeneticImmunologyCell CountSpleenDNA-binding proteinMiceTh2 CellsAntigens CDmedicineAnimalsImmunology and AllergyLectins C-TypeLymphocytesL-SelectinNuclear proteinTranscription factorLymphokinesNFATC Transcription FactorsbiologyChemistryLymphokineNuclear ProteinsGene deletionNFATC Transcription FactorsCell biologyDNA-Binding ProteinsHyaluronan Receptorsmedicine.anatomical_structureImmunologybiology.proteinL-selectinGene DeletionSpleenTranscription FactorsImmunology Letters
researchProduct

Inefficient Termination of Antigen Responses in NF-ATp-Deficient Mice

1998

In order to elucidate the role of NF-ATp, one of the most prominent members of family of NF-AT transcription factors in peripheral T lymphocytes, in T cell activation and differentiation we created NF-ATp-deficient mice by gene targeting. Such NF-ATp-/- mice are born and appear to develop a normal immune system. Apart from clear-cut defects in the synthesis of mRNAs for Th2-type lymphokines, such as IL-4, IL-5, IL-10 and IL-13, in primary and secondary stimulations of spleen cells in vitro, of a distinct impaired deletion of V beta 11+/CD4+ T lymphocytes from these mice was detected after superantigen injection. Moreover, NF-ATp-/- mice older than 6 weeks show an 2-5 fold increase in number…

T-LymphocytesT cellImmunologyApoptosisCell CountEnterotoxinsMiceImmune systemAntigenSuperantigenmedicineAnimalsHumansImmunology and AllergyCell Line TransformedB-LymphocytesLymphokinesSuperantigensNFATC Transcription FactorsbiologyCD44LymphokineNuclear ProteinsGene targetingHematologyMolecular biologyDNA-Binding Proteinsmedicine.anatomical_structureCell culturebiology.proteinGene DeletionTranscription FactorsImmunobiology
researchProduct