0000000001103516

AUTHOR

F Mosca

showing 6 related works from this author

Bovine lactoferrin prevents invasive fungal infections in very low birth weight infants: a randomized controlled trial.

2011

Background: Lactoferrin is a mammalian milk glycoprotein involved in innate immunity. Recent data show that bovine lactoferrin (bLF) prevents late-onset sepsis in preterm very low birth weight (VLBW) neonates. Methods: This is a secondary analysis of data from a multicenter randomized controlled trial where preterm VLBW neonates randomly received bLF (100 mg/day; group A1), bLF + Lactobacillus rhamnosus GG (106 colony-forming units per day; group A2), or placebo (group B) for 6 weeks. Here we analyze the incidence rates of fungal colonization, invasive fungal infection (IFI), and rate of progression from colonization to infection in all groups. Results: This study included 472 neonates who…

fungal sepsisDiseasesInfant Premature DiseasesPediatricsGastroenterologylactoferrin; VLBW neonates; Candida; fungal sepsis; prophylaxisGroup BSettore MED/38 - Pediatria Generale E SpecialisticaAnti-Infective AgentsInfant Very Low Birth WeightCandidabiologyLactoferrinBovine lactoferrin fungal infections very low birth weight newbornsPerinatology and Child Healthlactoferrinprophylaxismedicine.symptomInfant Prematuremedicine.medical_specialtyFungal sepsisPlaceboSepsisLactobacillus rhamnosusIntolerancesInternal medicinemedicineAnimalsHumansfungal sepsiAdverse effectPrematureProphylaxisbusiness.industryVery Low Birth WeightProbioticsInfant NewbornInfantNewbornbiology.organism_classificationmedicine.diseaseLactoferrinLow birth weightMycosesVLBW neonatesPediatrics Perinatology and Child HealthImmunologyCandida; Fungal sepsis; Lactoferrin; Prophylaxis; VLBW neonates; Animals; Anti-Infective Agents; Cattle; Humans; Infant Newborn; Infant Premature; Infant Premature Diseases; Lactoferrin; Mycoses; Probiotics; Infant Very Low Birth Weight; Pediatrics Perinatology and Child Healthbiology.proteinCattlebusiness
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Work environment, volume of activity and staffing in neonatal intensive care units in Italy: results of the SONAR-nurse study

2016

Background Neonatal units’ volume of activity, and other quantitative and qualitative variables, such as staffing, workload, work environment, care organization and geographical location, may influence the outcome of high risk newborns. Data about the distribution of these variables and their relationships among Italian neonatal units are lacking. Methods Between March 2010-April 2011, 63 neonatal intensive care units adhering to the Italian Neonatal Network participated in the SONAR Nurse study. Their main features and work environment were investigated by questionnaires compiled by the chief and by physicians and nurses of each unit. Twelve cross-sectional monthly-repeated surveys on diff…

Cross-sectional studyStaffingWorkloadCritical Care NursingPediatrics03 medical and health sciences0302 clinical medicineSettore MED/38 - Pediatria Generale E SpecialisticaNursing030225 pediatricsIntensive careCritical care nursingSurveys and QuestionnairesNeonatalIntensive Care Units NeonatalMedicineHumansSurveys and Questionnaire030212 general & internal medicineLocationWorkplaceCross-Sectional Studiebusiness.industryResearchNurse-Patient RelationInfant NewbornPatient AcuityInfantWorkloadPatient AcuityPerinatology and Child HealthNewbornInfant Newborn; Intensive Care Units Neonatal; Nurse-Patient Relations; Patient Acuity; Workload; Cross-Sectional Studies; Humans; Infant Newborn; Intensive Care Units Neonatal; Italy; Surveys and Questionnaires; Critical Care Nursing; Pediatric Nursing; Workload; WorkplacePediatric NursingInfant Newborn; Intensive Care Units Neonatal; Nurse-Patient Relations; Patient Acuity; WorkloadIntensive Care UnitsCross-Sectional StudiesItalyWorkforceInfant; Intensive care units; Neonatal; Newborn; Nurse-patient relations; Patient acuity; Workload; Cross-Sectional Studies; Humans; Infant Newborn; Intensive Care Units Neonatal; Italy; Surveys and Questionnaires; Critical Care Nursing; Pediatric Nursing; Workload; Workplace; Pediatrics Perinatology and Child HealthPediatric nursingbusinessNurse-Patient RelationsHuman
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Survey of neonatal respiratory support use in very preterm infants in Italy

2012

Background: Respiratory support in very preterm infants is often a life-saving procedure and several techniques are available. There is lack of data on the current use of these techniques. Methods and aim: We analyzed a cohort of infants <30 weeks gestation or < 1501 g birth weight, enrolled in the Italian Neonatal Network in 2009 and 2010 (n = 8297, mean gestation = 29.3 weeks, mean birth weight = 1089 g) to ascertain the use of several techniques. We also conducted a questionnaire survey of all neonatal units adhering to the Italian Neonatal Network, inquiring about preferred methods of respiratory support. Results: Conventional ventilation was used in 53% of these infants, high frequency…

Respiratory Therapymedicine.medical_specialtymedicine.medical_treatmentContinuous positive airway pressureVentilation; continuous positive airway pressure; variation; preterm infant; respiratory managementVariationmacromolecular substancesPediatricsrespiratory managementpreterm infantCohort StudiesSettore MED/38 - Pediatria Generale E SpecialisticaHumansMedicineContinuous positive airway pressureIntensive care medicinePrematureVentilation continuous positive airway pressure variation preterm infant respiratory managementbusiness.industryInfant NewbornInfantObstetrics and GynecologyPerinatology and Child HealthNewbornVentilationRespiratory supportVery pretermItalyPreterm infantPediatrics Perinatology and Child HealthRespiratory managementBreathingPremature BirthContinuous positive airway pressure; Preterm infant; Respiratory management; Variation; Ventilation; Cohort Studies; Humans; Infant Newborn; Infant Premature; Italy; Premature Birth; Respiratory Therapy; Pediatrics Perinatology and Child Health; Obstetrics and Gynecologyvariationpreterm neonates; respiratory distress syndrome; respiratory supportbusinesscontinuous positive airway pressureInfant PrematureThe Journal of Maternal-Fetal &amp; Neonatal Medicine
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40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

2004

0303 health sciencesmedicine.medical_specialtybusiness.industryEASDEndocrinology Diabetes and MetabolismHuman physiologymedicine.disease03 medical and health sciences0302 clinical medicineDiabetes mellitusFamily medicineInternal MedicineMedicinebusiness030217 neurology & neurosurgery030304 developmental biology
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Intersociety policy statement on the use of whole-exome sequencing in the critically ill newborn infant.

2017

Abstract The rapid advancement of next-generation sequencing (NGS) technology and the decrease in costs for whole-exome sequencing (WES) and whole-genome sequening (WGS), has prompted its clinical application in several fields of medicine. Currently, there are no specific guidelines for the use of NGS in the field of neonatal medicine and in the diagnosis of genetic diseases in critically ill newborn infants. As a consequence, NGS may be underused with reduced diagnostic success rate, or overused, with increased costs for the healthcare system. Most genetic diseases may be already expressed during the neonatal age, but their identification may be complicated by nonspecific presentation, esp…

0301 basic medicineMaleNeonatal intensive care unitDiseaseReview030105 genetics & heredityPediatricsWhole Exome SequencingNeonateNeonatalOutcome Assessment Health CareDiagnosisPolicy MakingExome sequencingSanger sequencingGenomelcsh:RJ1-570Perinatology and Child HealthSettore MED/38Intensive Care UnitsItalyWhole-exome sequencingPractice Guidelines as TopicsymbolsWESFemaleHumanDiagnosiNICUmedicine.medical_specialtyMendelian03 medical and health sciencessymbols.namesakeOutcome Assessment (Health Care)Neonatal ScreeningNeonatal intensive care unitGeneticIntensive Care Units NeonatalExome SequencingmedicineDiagnosis; Genetic; Genome; Mendelian; Neonatal intensive care unit; Neonate; NICU; WES; WGS; Whole-exome sequencing; Pediatrics Perinatology and Child HealthHumansGenetic TestingIntensive care medicineSettore MED/06 - ONCOLOGIA MEDICAGenetic heterogeneityCritically illbusiness.industryGenome HumanInfant NewbornInfantlcsh:PediatricsNewbornInfant newborn030104 developmental biologyDiagnosis; Genetic; Genome; Mendelian; NICU; Neonatal intensive care unit; Neonate; WES; WGS; Whole-exome sequencing; Female; Genetic Testing; Genome Human; Humans; Infant; Infant Newborn; Intensive Care Units Neonatal; Italy; Male; Neonatal Screening; Outcome Assessment (Health Care); Policy Making; Whole Exome Sequencing; Practice Guidelines as TopicPediatrics Perinatology and Child HealthDifferential diagnosisbusinessWGS
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POSTNATAL DEVELOPMENTAL CHANGES IN ENTERIC DOPAMINERGIC SYSTEM

2013

The postnatal period is a key period of life, characterized by the maturation of various organs and in particular of the gut. Currently, we have a poor understanding of the development of neurological and endocrine factors that control intestinal motility. Such knowledge can provide indications about the potency, efficacy, or therapeutic range of a drug in premature infants. Dopaminegic antagonists are often used as prokinetic drugs to treat impaired GI propulsion, although the role of the enteric dopaminergic system in the control of intestinal motility in neonatal vs adult has not been adequately addressed. In this view the aim of this study, was to examine, the functionality of the dopam…

postnatal developmentdopaminergic systementeric nervous systemSettore BIO/09 - Fisiologia
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