0000000001106157

AUTHOR

Jan A. Staessen

showing 14 related works from this author

Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018…

2018

Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean dia…

systolic blood pressureSettore MED/09 - Medicina Internablood pressure measurementHEALTH EXAMINATION SURVEYSBlood Pressure ; Hypertension ; Population Health ; Global Health ; Non-communicable DiseaseEpidemiology[SDV]Life Sciences [q-bio]global healthSouth Asia//purl.org/pe-repo/ocde/ford#3.03.09 [https]kohonnut verenpaineMedicine and Health Sciencesmiddle income countrymeasurement methodskin and connective tissue diseasesVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771Public Environmental & Occupational HealthadultPopulation healthpublic healthblood pressure regulationPublic Health Global Health Social Medicine and EpidemiologyNon-communicable diseasekansainvälinen vertailuhealth surveyagedfemalepriority journalHypertensionBlood pressuremean arterial pressureGLOBAL TRENDSSODIUM-INTAKELife Sciences & Biomedicinesurvey designhypertensionprevalenceGlobal healthUNITED-STATESURBAN COMMUNITIESArticleSECULAR TRENDSMiddle EastCentral Asiamaledisease prevalence[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemkansanterveysbloodSYSTEMATIC ANALYSIShumanverenpainetautiBlood pressure; Global health; Hypertension; Non-communicable disease; Population health; Epidemiology; public health;non-communicable diseaseScience & TechnologyPacific Oceanhigh income countrydiastolic blood pressurePacific RimBlood pressure; Global health; Hypertension; Non-communicable disease; Population healthBlood Pressure - Epidemiology - PopulationNorth Africamajor clinical studyHYPERTENSION PREVALENCEverenpaineFolkhälsovetenskap global hälsa socialmedicin och epidemiologiARTERIAL-HYPERTENSION[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologiePOTASSIUM INTAKEsense organstrend analysistrend studypopulation researchpopulation health[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologylow income country
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Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight

2021

From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia…

Population -- Health aspectsLeannessBaixo peso/UnderweightnoneDouble burdenalipainoisuustulotasoglobal healthsystematic analysisSedentary behaviorsRC1200Prospective associations0302 clinical medicineunderweightnälänhätäBiology (General)skin and connective tissue diseasesChildrenComputingMilieux_MISCELLANEOUSBody mass indexHuman Nutrition & Healtheducation.field_of_studyHumane Voeding & GezondheidylipainoGeneral Medicinekansainvälinen vertailu3. Good healthWorld healthMedicineA100 Pre-clinical MedicinePopulation distributionmedicine.medical_specialtyQH301-705.5ScienceSocio-culturaleNursing.Social sciencesGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesThinnessSDG 3 - Good Health and Well-beingBMI; epidemiology; global health; none; obesity; underweightNoneHumansObesidade/ObesitySDG 2 - Zero HungereducationVLAGUS adultsOmvårdnadbody mass index; malnutrition; obesity underweightnutritional and metabolic diseasesmedicine.diseaseterveellisyysObesityFaculdade de Ciências SociaisBMI; epidemiology; global health; none; obesity; underweight; Body Mass Index; Humans; Obesity; Prevalence; Risk Factors; ThinnessGeneral BiochemistryWIASlihavuusunderweight ; obesity ; BMIBody mass indexRADemographyN.A.double burdenobesitySettore MED/09 - Medicina Internaalueelliset erotNutrition and DiseaseAnimal Nutrition[SDV]Life Sciences [q-bio]Medizin030204 cardiovascular system & hematology0601 Biochemistry and Cell BiologyChange distribution of body mass indexRisk FactorsRA0421Voeding en ZiekteEpidemiologyPrevalenceMedicine and Health SciencesGlobal healthÍndice de massa corporal/Body Mass Index030212 general & internal medicineUnderweightpainoindeksi2. Zero hungerGeneral NeuroscienceQRaliravitsemuselintarvikkeethealthPublic Health Global Health Social Medicine and EpidemiologyDiervoeding3142 Public health care science environmental and occupational health//purl.org/pe-repo/ocde/ford#3.01.03 [https]/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingChinese adultsepidemiologypooled analysisUnderweightmedicine.symptomDiet qualityB120 PhysiologyResearch Articletrends//purl.org/pe-repo/ocde/ford#1.06.03 [https]prevalencePopulationMothersGenetics and Molecular Biologybody mass indexmalnutrition3121 Internal medicineBMImedicineLife Scienceddc:6103125 Otorhinolaryngology ophthalmologyObesitykehonkoostumusNutritionAustralian adultsGeneral Immunology and Microbiology//purl.org/pe-repo/ocde/ford#3.01.04 [https]Ciências sociaisFolkhälsovetenskap global hälsa socialmedicin och epidemiologiMalnutritionEpidemiology and Global Healthsense organsEstilos de Vida e Impacto na Saúde
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European Society of Hypertension practice guidelines for ambulatory blood pressure monitoring

2014

Given the increasing use of ambulatory blood pressure monitoring (ABPM) in both clinical practice and hypertension research, a group of scientists, participating in the European Society of Hypertension Working Group on blood pressure monitoring and cardiovascular variability, in year 2013 published a comprehensive position paper dealing with all aspects of the technique, based on the available scientific evidence for ABPM. The present work represents an updated schematic summary of the most important aspects related to the use of ABPM in daily practice, and is aimed at providing recommendations for proper use of this technique in a clinical setting by both specialists and practicing physici…

AdultMalemedicine.medical_specialtyAmbulatory blood pressureAdolescentPhysiologyMEDLINEPharmacyWhite coat hypertensionPractice PatternsBlood Pressure MonitoringMasked HypertensionAtrial FibrillationAmbulatoryInternal MedicinemedicineHumansambulatory blood pressure monitoring arterial hypertension clinic blood pressure measurement clinical indications guidelines home blood pressure measurement practice recommendationsObesityPractice Patterns Physicians'ChildIntensive care medicineReimbursementPhysicians'business.industryMED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLAREBlood Pressure Monitoring Ambulatorymedicine.disease3. Good healthMasked HypertensionBlood pressureHypertensionPosition paperFemaleCardiology and Cardiovascular MedicinebusinessSoftwareWhite Coat HypertensionJournal of Hypertension
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Rising rural body-mass index is the main driver of the global obesity epidemic in adults

2019

Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions…

MaleRural PopulationobesityObesity body mass indexSettore MED/09 - Medicina InternaLetterUrban PopulationEpidemiology[SDV]Life Sciences [q-bio]humanosbody-mass indexadolescenteGeographic MappingSex Factorpaíses desarrolladosRural Health//purl.org/pe-repo/ocde/ford#3.03.09 [https]systematic analysisBody Mass Indexpaíses en desarrollo80 and overrisk factorsAge Factorphysical-activitymediana edadmapeo geográficoAged 80 and overanciano//purl.org/pe-repo/ocde/ford#3.02.18 [https]dietaAge FactorshealthadultoMiddle AgedMultidisciplinary Sciencesadulto joven[SDV] Life Sciences [q-bio]estado nutricionalnutritionScience & Technology - Other TopicsNUTRITIONFemaleHEALTHpooled analysisDiet Healthyworldwide trendsHumanDeveloped CountrieAdultAdolescent//purl.org/pe-repo/ocde/ford#3.03.04 [https]FOOD SYSTEMSocio-culturaleNutritional StatusURBANAdolescent; Adult; Age Factors; Aged; Aged 80 and over; Developed Countries; Developing Countries; Diet Healthy; Female; Geographic Mapping; Humans; Male; Middle Aged; Obesity; Rural Health; Rural Population; Sex Factors; Urban Health; Urban Population; Young Adult; Body Mass Index; Nutritional StatusPOOLED ANALYSISDeveloping CountrieYoung AdultSex FactorsMIDDLE-INCOME COUNTRIESSYSTEMATIC ANALYSISHumansUrban rural Obesity Body-Mass-IndexObesityobesidadDeveloping CountriesAgedMiddle-income countries; obesity; physical-activity; systematic analysis; worldwide trends; pooled analysis; food system; urban; health; nutrition; weightHealthyScience & TechnologyMiddle-income countriesDeveloped Countriesíndice de masa corporalUrban HealthweightDietPHYSICAL-ACTIVITYWORLDWIDE TRENDSRisk factors[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologieWEIGHTfood systemurban
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From pioneering to implementing automated blood pressure measurement in clinical practice: Thomas Pickeringʼs legacy

2010

Thomas G. Pickering spent most of his scientific career in carrying out research on clinical hypertension and blood pressure (BP) measurement. In our review of Pickering's seminal work, we first focused on white-coat hypertension and masked hypertension, two terms that he had introduced. Next, we highlighted the early publications of Pickering on diurnal BP variability and on the clinical application of self-measured BP. Pickering's work inspired many investigators worldwide and constituted a solid basis for further research. Pickering's original ideas led to algorithms for risk stratification involving white-coat hypertension and masked hypertension, diurnal BP variability, and self-measur…

MaleGerontologymedicine.medical_specialtyAmbulatory blood pressureAdolescentScientific careerConditioning ClassicalCardiologyWhite coat hypertension030204 cardiovascular system & hematologyAssessment and DiagnosisHistory 21st Century03 medical and health sciences0302 clinical medicineself-measured blood pressureInternal MedicinemedicineHumansBlood pressure monitoringmasked hypertension030212 general & internal medicineChildIntensive care medicineAdvanced and Specialized Nursingbusiness.industryblood pressureGeneral MedicineBlood Pressure Monitoring AmbulatoryHistory 20th Centurymedicine.diseaseCircadian RhythmClinical PracticeMasked HypertensionBlood pressureCardiovascular DiseasesHypertensionRisk stratificationFemaleCardiology and Cardiovascular Medicinebusinessdiurnal blood pressure variabilitywhite-coat hypertensionBlood Pressure Monitoring
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Author response: Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight

2020

education.field_of_studybusiness.industryPopulationDistribution (economics)medicine.diseaseObesityGeographymedicineUnderweightmedicine.symptomeducationbusinessBody mass indexDemography
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European Society of Hypertension recommendations for conventional, ambulatory and home blood pressure measurement

2003

IntroductionOver the past 20 years or so, the accuracy of the conventional Riva-Rocci/Korotkoff technique of blood pressure measurement has been questioned and efforts have been made to improve the technique with automated devices. In the same period, recognition of the phenomenon of white-coat hype

medicine.medical_specialtyPhysiologyBlood PressureSphygmomanometer030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicineInternal MedicinemedicineHumansBlood pressure monitoring030212 general & internal medicineHypertension diagnosisIntensive care medicineSocieties MedicalMicrolifebusiness.industryBlood Pressure Monitoring AmbulatoryEuropeSelf CareMasked HypertensionBlood pressureCardiovascular DiseasesHypertensionAmbulatorySelf careCardiology and Cardiovascular MedicinebusinessJournal of Hypertension
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A century of trends in adult human height

2016

Article

estatura corporalEpidemiologyComputingMilieux_LEGALASPECTSOFCOMPUTINGmedical research;pituuskasvuGlobal Healthmedical research0302 clinical medicineadultsPublic health surveillanceBiology (General)ComputingMilieux_MISCELLANEOUSheight ; global ; trendsPOPULATIONHuman Nutrition & Healthbiological sciences;education.field_of_studyEVOLUÇÃO HUMANAbiological sciencesHumane Voeding & GezondheidGeneral MedicineadultoHälsovetenskaperBiological sciencesnutritionOF-THE-LITERATUREMedicineGROWTHHEALTHPublic HealthHumanQH301-705.5ScienceSECULAR CHANGESSocio-culturaleGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesEpidemiology; Public HealthMedical researchNoneHealth SciencesHumansHuman heighteducationVLAGNeuroscience (all)Biochemistry Genetics and Molecular Biology (all)Adult human heightCHILD UNDERNUTRITION030104 developmental biologyBody mass index030217 neurology & neurosurgeryheightDemography0301 basic medicineSettore MED/09 - Medicina InternaNutrition and DiseaseImmunology and Microbiology (all)[SDV]Life Sciences [q-bio]humanosbiological sciences; epidemiology; global health; medical research; none; nutritionVoeding en ZiekteStature -- History -- 20th centuryMedicine and Health SciencesBiological sciencesaikuisetGeneral NeuroscienceQRPublic Health Global Health Social Medicine and EpidemiologyBody sizenone;biological sciences; epidemiology; global health; medical research; none; nutrition; Adult; Global Health; Humans; Body Height; Neuroscience (all); Biochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all)epidemiology;Adult height//purl.org/pe-repo/ocde/ford#3.01.03 [https]Research Articletrendsglobal health;AdultSTATURESouth asia//purl.org/pe-repo/ocde/ford#1.06.03 [https]Stature TallPopulationGlobal healthJournal ArticleLife ScienceGeneral Immunology and Microbiologybiological science//purl.org/pe-repo/ocde/ford#3.01.04 [https]Quarter (United States coin)Body HeighttrenditBODY-MASS INDEXFolkhälsovetenskap global hälsa socialmedicin och epidemiologikorkeusEpidemiology and Global HealthCancer incidenceCANCER INCIDENCEWEIGHT
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Practice guidelines of the European Society of Hypertension for clinic, ambulatory and self blood pressure measurement.

2005

Introduction Blood pressuremeasurement is the basis for the diagnosis, management, treatment, epidemiology and research of hypertension, and the decisions affecting these aspects of hypertensionwill be influenced, for better or worse, by the accuracyofmeasurement.Anaccuratebloodpressure reading is a prerequisite, therefore, regardless of which technique is used, yet all too often the accuracy of measurement is taken for granted or ignored. This paper is a summary up-dated version of the recommendations published by the European Society of Hypertension (ESH) Working Group on Blood Pressure Monitoring for conventional (CBPM), ambulatory (ABPM) and self (SBPM) blood pressure measurement in 200…

medicine.medical_specialtyPhysiologybusiness.industryMEDLINESphygmomanometerGuidelineBlood Pressure Monitoring AmbulatoryAmbulatory care nursingEuropeSelf CareBlood pressureEpidemiologyAmbulatoryHypertensionInternal MedicinemedicineHumansBlood pressure monitoringCardiology and Cardiovascular MedicinebusinessIntensive care medicineHumanJournal of hypertension
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Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million …

2016

Copyright © NCD Risk Factor Collaboration. Open Access article distributed under the terms of CC BY.

MaleObesidadCHILDRENSaludReviewpaíses desarrolladosGlobal HealthBody Mass IndexBody mass index population study0302 clinical medicineModelsFactores de riesgo cardiovascularMedicinebody mass index ; underweight ; overweight ; obesityYoung adultHuman Nutrition & Healtheducation.field_of_studyHumane Voeding & GezondheidGeneral MedicineASSOCIATION11 Medical And Health Sciencesadultopredicciónadulto jovenCARDIOVASCULAR-DISEASEthinness/epidemiologyNONCOMMUNICABLE DISEASESNCD Risk Factor Collaboration (NCD-RisC)Enfermedades cardiovascularesDeveloped countryteorema de BayesMedical sciences03 medical and health sciencesSDG 3 - Good Health and Well-beingThinnessHumanseducationDeveloping CountriesobesidadVLAGScience & TechnologyModels StatisticalCAUSE-SPECIFIC MORTALITYBayes Theoremmedicine.diseaseQPObesityadult body-massIndice de masa corporal (IMC)RISK-FACTORSAdolescent; Adult; Bayes Theorem; Body Mass Index; Developed Countries; Developing Countries; Female; Forecasting; Global Health; Humans; Male; Models Statistical; Obesity/epidemiology; Prevalence; Thinness/epidemiology; Young AdultRABody mass indexDemographyMeta-AnalysisGerontologySettore MED/09 - Medicina InternaNutrition and DiseasehumanosadolescenteOverweightpaíses en desarrolloVoeding en ZiekteMedicine and Health SciencesGlobal healthPrevalence030212 general & internal medicineNon-U.S. Gov'tMedicine (all)Research Support Non-U.S. Gov'tprevalenciaPublic Health Global Health Social Medicine and EpidemiologyStatisticalAdolescent; Adult; Bayes Theorem; Developed Countries; Developing Countries; Female; Forecasting; Humans; Male; Models Statistical; Obesity; Prevalence; Thinness; Young Adult; Body Mass Index; Global Health; Medicine (all)/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemaleUnderweightmedicine.symptompooled analysisLife Sciences & Biomedicineobesity/*epidemiologyAdultAdolescentPopulation030209 endocrinology & metabolismResearch SupportYoung AdultMedicine General & InternalEPIDEMICGeneral & Internal MedicineJournal ArticleLife Scienceddc:610ObesityObesidad morbidaOBESITY PREVENTIONOVERWEIGHTbusiness.industryDeveloped Countriesíndice de masa corporalCOHORTS//purl.org/pe-repo/ocde/ford#3.02.00 [https]Folkhälsovetenskap global hälsa socialmedicin och epidemiologiCiencias socio biomédicasbusinessdelgadezForecasting
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Morbidity and mortality on combination versus monotherapy in the Systolic Hypertension in Europe Trial

2009

medicine.medical_specialtySystolic hypertensionbusiness.industryEmergency medicinemedicineCardiology and Cardiovascular Medicinemedicine.diseaseIntensive care medicinebusinessInternational Journal of Cardiology
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Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331…

2015

Diabetes has been defined on the basis of different biomarkers, including fasting plasma glucose (FPG), 2-h plasma glucose in an oral glucose tolerance test (2hOGTT), and HbA1c. We assessed the effect of different diagnostic definitions on both the population prevalence of diabetes and the classification of previously undiagnosed individuals as having diabetes versus not having diabetes in a pooled analysis of data from population-based health examination surveys in different regions.

Maleendocrine system diseasesEndocrinology Diabetes and Metabolismmedicine.medical_treatmentGlobal Health0302 clinical medicineEndocrinologyeducation.field_of_studyDiabetis//purl.org/pe-repo/ocde/ford#3.02.18 [https]Diabetes Mellitus/blood/diagnosis/epidemiologySciences bio-médicales et agricolesadultosensibilidad y especificidadhealth survey3. Good healthpriority journalCARDIOVASCULAR-DISEASEdiabetes mellitusmedicine.medical_specialtyglucosa sanguíneaSurvey samplingoral glucose tolerance test.Medical sciencesSensitivity and SpecificityArticleEndocrinology Diabetes and Metabolism; Internal Medicine; EndocrinologyEffects of diabetesHemoglobin A Glycosylated/metabolism03 medical and health sciencesfalse positive resultSDG 3 - Good Health and Well-beingDiabetes prevalenceDiabetes MellitusSYSTEMATIC ANALYSISHumanshumandiagnostic test accuracy studygross national productOLDER-ADULTSeducationprueba de tolerancia a la glucosaglycosylated hemoglobinHEMOGLOBIN A(1C) MEASUREMENTVLAGGlycated HemoglobinHemoglobin A GlycosylatedScience & TechnologyBlood Glucose/metabolismnutritional and metabolic diseasesGlucose Tolerance Testeconomic aspectmedicine.diseaseglucose blood levelGlucoseEndocrinologyagechemistryFaculdade de Ciências SociaisGlucosaGlobal surveillance of diabetesTOLERANCE TESTWORLDWIDE STANDARDIZATIONBiomarkersBiomedical sciencesBlood GlucoseSettore MED/09 - Medicina InternaNutrition and DiseasehumanosBiomarkers/metabolismInternal Medicine; Endocrinology Diabetes and Metabolism; Endocrinologygeographychemistry.chemical_compoundVoeding en ZiekteDiagnosisPrevalenceMedicine and Health Sciencesvigilancia centinela030212 general & internal medicinehemoglobin A1cUS POPULATIONDiabetes diagnosisGlucose tolerance testINSULIN-RESISTANCEmedicine.diagnostic_testResearch Support Non-U.S. Gov'tQDiabetesprevalenciaSCREENING-TESThealthArticlesGlucose bloodDiabetes and MetabolismincomePopulation-based health examination surveysFemaleLife Sciences & BiomedicineAdultPopulationpopulation groupCONSENSUS STATEMENT030209 endocrinology & metabolismGLYCATED HEMOGLOBINhigh income regionEndocrinology & MetabolismInsulin resistanceResearch Support N.I.H. ExtramuralbloodInternal medicineDiabetes mellitusparasitic diseasesJournal ArticlemedicineInternal MedicineLife Scienceddc:613business.industryInsulinbody massBiological markerFASTING PLASMA-GLUCOSECiencias socio biomédicasGlycated hemoglobinbusinessmetabolismSentinel Surveillance
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Diastolic left ventricular function in relation to circulating metabolic biomarkers in a population study

2019

AimsWe studied the association of circulating metabolic biomarkers with asymptomatic left ventricular diastolic dysfunction, a risk-carrying condition that affects 25% of the population.Methods and resultsIn 570 randomly recruited people, we assessed in 2005–2010 and in 2009–2013 the multivariable-adjusted correlations of e’ (early left ventricular relaxation) and E/e’ (left ventricular filling pressure) measured by Doppler echocardiography with 43 serum metabolites, quantified by magnetic resonance spectroscopy. In 2009–2013, e’ cross-sectionally increased (Bonferroni corrected p ≤ 0.016) with the branched-chain amino acid valine (per one standard deviation increment, +0.274 cm/s (95% conf…

MaleCardiac & Cardiovascular SystemsMagnetic Resonance SpectroscopyTime FactorsEpidemiology030204 cardiovascular system & hematologyVentricular Function LeftVentricular Dysfunction Left0302 clinical medicineBelgiumpopulation scienceDiastole030212 general & internal medicinebranched-chain amino acidsMetabolic biomarkersVentricular functionIncidenceMiddle AgedRNA Transfer Amino Acid-SpecificPrognosismetabolomicsEchocardiography DopplerGLUTAMINECardiologyPopulation studyHEART-FAILUREFemalemedicine.symptomCardiology and Cardiovascular MedicineLife Sciences & BiomedicineAdultmedicine.medical_specialtyDiastoleAsymptomatic03 medical and health sciencesPredictive Value of TestsInternal medicineATRIALmedicineHumansAgedScience & Technologybusiness.industryBiomarkerDYSFUNCTIONBiomarker (cell)diastolic left ventricular dysfunctionAsymptomatic DiseasesCardiovascular System & CardiologyLeft ventricular diastolic dysfunctionTransfer RNA AminoacylationbusinessAmino Acids Branched-ChainBiomarkers
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An investigation of antihypertensive class, dementia, and cognitive decline

2019

Objective High blood pressure is one of the main modifiable risk factors for dementia. However, there is conflicting evidence regarding the best antihypertensive class for optimising cognition. Our objective was to determine whether any particular class of antihypertensive was associated with a reduced risk of cognitive decline or dementia using comprehensive meta-analysis including reanalysis of original participant data. Methods To identify suitable studies MEDLINE, Embase and PsycINFO® and pre-existing study consortia were searched from inception to December 2017. Authors of prospective longitudinal human studies or trials of antihypertensives were contacted for data-sharing and collabor…

TansleyBlood pressureDementiaAntihypertensive
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