Author: A De Araujo

0000000001107728

AUTHOR

A De Araujo

showing 1 related works from this author

Docosahexaenoic acid protects human RPE cells against oxidative stress via PI3K/Akt m-TOR/p70-p85S6K pathways

2012

Purpose Oxidative Stress (OS) plays a critical role in the pathogenesis of age-related macular degeneration (AMD), especially by targeting the retinal pigment epithelium (RPE). Dietary habits with high consumption of docosahexaenoic acid (DHA) have been shown to prevent the development and evolution of AMD. Nevertheless, it is still unclear how DHA affects AMD. Our study aimed to investigate the involvement of the PI3K/Akt and m-TOR/p70-p85S6K pathways in human RPE cells after induction of OS, and then to assess the effect of DHA in the signaling pathways and in the protection against RPE cell death. Methods For this purpose, we used ARPE-19 cells exposed to the prooxidant agent, tert-butyl…

Programmed cell deathmacular degenerationP70-S6 Kinase 1Biologymedicine.disease_cause03 medical and health sciences0302 clinical medicine[ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathologymedicineoxidative stress[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory OrgansProtein kinase BPI3K/AKT/mTOR pathway030304 developmental biology0303 health sciencesacide docosahexaénoiquestress oxydatifGeneral Medicinedégénérescence maculaireeye diseasesCell biologyOphthalmologyDocosahexaenoic acidBiochemistryDocosahexaenoic acidApoptosis030220 oncology & carcinogenesis[ SDV.MHEP.OS ] Life Sciences [q-bio]/Human health and pathology/Sensory OrgansPhosphorylationsense organsOxidative stress[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

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PEPhysical Sciences and Engineering
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